Department of Pharmacology, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
Adv Exp Med Biol. 2019;1206:199-220. doi: 10.1007/978-981-15-0602-4_10.
Autophagy is an important metabolic pathway of cells. Cells degrade harmful intracellular components with the aid of autophagy to maintain a healthy state. In recent decades, the study of non-coding RNA in the regulation of autophagy has been a hot area. Mounting evidence indicates that many ncRNAs are involved in the dynamic process of autophagy, and further studies were undertaken to dissect the detailed cellular and molecular mechanisms underlying this process. In this chapter, we mainly summarized the regulation of different non-coding RNAs in autophagy as well as the detailed mechanisms. Based on these findings, we also discussed the roles of non-coding RNAs in the diagnosis, treatment, and prognosis of diseases with an emphasis on their use as potential biomarkers and therapeutic targets for different diseases.
自噬是细胞的一种重要代谢途径。细胞借助自噬降解有害的细胞内成分，以维持健康状态。近几十年来，非编码 RNA 在自噬调控中的研究成为热点。越来越多的证据表明，许多 ncRNA 参与自噬的动态过程，并进一步研究以剖析该过程的详细细胞和分子机制。在本章中，我们主要总结了不同非编码 RNA 对自噬的调控及其详细机制。基于这些发现，我们还讨论了非编码 RNA 在疾病的诊断、治疗和预后中的作用，重点讨论了它们作为不同疾病潜在生物标志物和治疗靶点的用途。
