Department of Cardiology, DeltaHealth Hospital•Shanghai, No. 109, Xule Road, Xujing Town, Qingpu District, Shanghai, 201702, China.
Department of Cardiology, Affiliated Hospital of Yangzhou University, Yangzhou, 225001, China.
J Cardiothorac Surg. 2024 Sep 6;19(1):517. doi: 10.1186/s13019-024-03036-8.
The purpose of this study was to investigate the diagnostic value of circ_0013958 in acute myocardial infarction (AMI) patients and its influence on the prognosis of AMI patients.
The GSE160717 dataset was downloaded from the NCBI database and differentially expressed genes were analyzed between the control group and the AMI group. The up-regulated genes included circ_0013958. The expression of circ_0013958 in both groups was further verified by RT-qPCR. The Receiver Operating Characteristic curve was used to evaluate the diagnostic value of circ_0013958 in AMI. Pearson correlation analysis was used to examine the correlation between circ_0013958 levles and biochemical indicators. Binary logistic regression was used to analyze the risk factors affecting the occurrence of AMI. Prognostic analysis was performed using COX regression analysis and the Kaplan-Meier Curve.
Compared to the control group, the level of circ_0013958 in AMI patients increased. Circ_0013958 can effectively distinguish AMI patients from non-AMI patients. Circ_0013958 levels were positively correlated with cTnI, LDH, CRP and TC levels. The elevated level of circ_0013958 was an independent risk factor for the occurrence of AMI. Higher circ_0013958 levels were also associated with the occurrence of major adverse cardiac events (MACEs) in AMI patients. Additionally, elevated circ_0013958 levels reduced the survival probability of AMI patients.
Circ_0013958 levels were up-regulated in AMI patients. It can be used as a diagnosis biomarker for AMI. The level of circ_0013958 was correlated with the disease severity and was an independent risk factor for the occurrence of AMI. Elevated circ_0013958 levels were associated with poor prognosis in AMI patients.
本研究旨在探讨 circ_0013958 在急性心肌梗死（AMI）患者中的诊断价值及其对 AMI 患者预后的影响。
从 NCBI 数据库下载 GSE160717 数据集，分析对照组和 AMI 组之间的差异表达基因。上调基因包括 circ_0013958。进一步通过 RT-qPCR 验证两组 circ_0013958 的表达。利用受试者工作特征曲线评估 circ_0013958 在 AMI 中的诊断价值。采用 Pearson 相关分析检验 circ_0013958 水平与生化指标的相关性。采用二项逻辑回归分析影响 AMI 发生的危险因素。采用 COX 回归分析和 Kaplan-Meier 曲线进行预后分析。
与对照组相比，AMI 患者的 circ_0013958 水平升高。circ_0013958 能够有效区分 AMI 患者和非 AMI 患者。circ_0013958 水平与 cTnI、LDH、CRP 和 TC 水平呈正相关。circ_0013958 水平升高是 AMI 发生的独立危险因素。circ_0013958 水平升高与 AMI 患者主要不良心脏事件（MACEs）的发生有关。此外，circ_0013958 水平升高还降低了 AMI 患者的生存概率。
AMI 患者中 circ_0013958 水平上调。它可以作为 AMI 的诊断生物标志物。circ_0013958 水平与疾病严重程度相关，是 AMI 发生的独立危险因素。circ_0013958 水平升高与 AMI 患者预后不良相关。
