Picciani Bruna Lavinas Sayed, Domingos Tábata Alves, Teixeira-Souza Thays, Fausto-Silva Anna Karoline, Dias Eliane Pedra, Carneiro Sueli
Department of Pathology, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brazil.
Graduate Program in Pathology, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brazil.
An Bras Dermatol. 2019 Nov-Dec;94(6):677-683. doi: 10.1016/j.abd.2019.01.006. Epub 2019 Oct 24.
Psoriasis is a skin-articular disease with unclear etiopathogenesis. It has been suggested that the disease is immune-mediated by T-lymphocytes, predominantly Th17 cells. Similar to psoriasis, geographic tongue is an inflammatory disease with participation of Th17 cells and direct correlation with psoriasis.
To investigate and compare the inflammatory responses and the Th17 pathway in psoriasis and geographic tongue.
This was a cross-sectional study with 46 participants that were categorized into three groups: (A) patients with psoriasis vulgaris; (B) patients with geographic tongue and psoriasis; (C) patients with geographic tongue without psoriasis. All patients underwent physical examination, and a skin and oral biopsy for histopathological examination and immunohistochemical analysis with anti-IL6, anti-IL17, and anti-IL23 antibodies.
Histological analysis of all lesions showed mononuclear inflammatory infiltrate. However, moderate intensity was prevalent for the patients with geographic tongue and psoriasis and geographic tongue groups. Immunopositivity for the antibodies anti-IL6, anti-IL17, and anti-IL23 revealed cytoplasmic staining, mainly basal and parabasal, in both psoriasis and geographic tongue. Regarding IL-6, in patients with geographic tongue and psoriasis cases the staining was stronger than in patients with geographic tongue without psoriasis cases. IL-17 evidenced more pronounced and extensive staining when compared to the other analyzed interleukins. IL-23 presented similar immunopositivity for both geographic tongue and psoriasis, demonstrating that the neutrophils recruited into the epithelium were stained.
This study was limited by the number of cases.
The inflammatory process and immunostaining of IL-6, IL-17, and IL-23 were similar in geographic tongue and psoriasis, suggesting the existence of a type of geographic tongue that represents an oral manifestation of psoriasis.
银屑病是一种病因发病机制不明的皮肤关节疾病。有研究表明，该疾病是由T淋巴细胞介导的免疫反应，主要是Th17细胞。与银屑病相似，地图舌是一种有Th17细胞参与且与银屑病直接相关的炎症性疾病。
研究并比较银屑病和地图舌的炎症反应及Th17通路。
这是一项横断面研究，46名参与者被分为三组：（A）寻常型银屑病患者；（B）地图舌合并银屑病患者；（C）无银屑病的地图舌患者。所有患者均接受体格检查，并进行皮肤和口腔活检，以进行组织病理学检查及使用抗IL6、抗IL17和抗IL23抗体进行免疫组化分析。
所有病变的组织学分析均显示单核细胞炎症浸润。然而，地图舌合并银屑病组和地图舌组中炎症强度以中度为主。抗IL6、抗IL17和抗IL23抗体的免疫阳性显示，银屑病和地图舌中均有细胞质染色，主要位于基底和副基底细胞层。关于IL-6，地图舌合并银屑病患者的染色强于无银屑病的地图舌患者。与其他分析的白细胞介素相比，IL-17的染色更明显且广泛。IL-23在地图舌和银屑病中的免疫阳性相似，表明募集到上皮中的中性粒细胞被染色。
本研究受病例数量限制。
地图舌和银屑病的炎症过程以及IL-6、IL-17和IL-23的免疫染色相似，提示存在一种可作为银屑病口腔表现的地图舌类型。
