• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

代谢综合征可减轻溃疡性结肠炎：与白细胞介素-10 和半乳糖凝集素-3 表达的相关性。

Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression.

机构信息

Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia.

出版信息

World J Gastroenterol. 2019 Nov 21;25(43):6465-6482. doi: 10.3748/wjg.v25.i43.6465.

DOI:10.3748/wjg.v25.i43.6465
PMID:31798282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6881509/
Abstract

BACKGROUND

Ulcerative colitis (UC) is a chronic disease characterized by inflammation of intestinal epithelium, primarily of the colon. An increasing prevalence of metabolic syndrome (MetS) in patients with UC has been documented recently. Still, there is no evidence that MetS alters the course of the UC.

AIM

To test the influence of the MetS on the severity of UC and the local and systemic immune status.

METHODS

Eighty nine patients with histologically confirmed UC were divided in two groups, according to ATP III criteria: Group without MetS (no MetS) and group with MetS.

RESULTS

Clinically and histologically milder disease with higher serum level of immunosuppressive cytokine interleukin-10 (IL-10) and fecal content of Galectin-3 (Gal-3) was observed in subjects with UC and MetS, compared to subjects suffering from UC only. This was accompanied with predomination of IL-10 over pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and interleukin-17 (IL-17) in the sera as well as Gal-3 over TNF-α and IL-17 in feces of UC patients with MetS. Further, the patients with both conditions (UC and MetS) had higher percentage of IL-10 producing and Gal-3 expressing innate and acquired immune cells in lamina propria.

CONCLUSION

Local dominance of Gal-3 and IL-10 over pro-inflammatory mediators in patients with MetS may present a mechanism for limiting the inflammatory process and subsequent tissue damage in UC.

摘要

背景

溃疡性结肠炎（UC）是一种以结肠为主的肠道上皮炎症性疾病，其特征为慢性疾病。最近有文献报道，代谢综合征（MetS）在 UC 患者中的发病率不断增加。然而，目前尚无证据表明 MetS 会改变 UC 的病程。

目的

检测代谢综合征对 UC 严重程度、局部和全身免疫状态的影响。

方法

根据 ATP III 标准，将 89 例组织学确诊为 UC 的患者分为两组：无代谢综合征组（无 MetS）和代谢综合征组（有 MetS）。

结果

与仅患有 UC 的患者相比，患有 UC 且合并 MetS 的患者其疾病的临床和组织学表现更为轻微，血清中免疫抑制细胞因子白细胞介素-10（IL-10）和粪便中半乳糖凝集素-3（Gal-3）水平更高。这与血清中促炎细胞因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-17（IL-17）中 IL-10 占优势，以及粪便中 Gal-3 占优势，TNF-α和 IL-17 在患有 UC 且合并 MetS 的患者中更为明显。此外，合并 UC 和 MetS 的患者固有和获得性免疫细胞在黏膜固有层中产生更多的 IL-10 和表达 Gal-3。

结论

MetS 患者中 Gal-3 和 IL-10 对促炎介质的局部优势可能是限制 UC 炎症过程和随后组织损伤的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/5d34370ab388/WJG-25-6465-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/9fc6386b2873/WJG-25-6465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/aa2a0342fa99/WJG-25-6465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/a688d4c58d9f/WJG-25-6465-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/4e048df54817/WJG-25-6465-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/5d34370ab388/WJG-25-6465-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/9fc6386b2873/WJG-25-6465-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/aa2a0342fa99/WJG-25-6465-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/a688d4c58d9f/WJG-25-6465-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/4e048df54817/WJG-25-6465-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/228c/6881509/5d34370ab388/WJG-25-6465-g005.jpg

相似文献

1
Metabolic syndrome attenuates ulcerative colitis: Correlation with interleukin-10 and galectin-3 expression.代谢综合征可减轻溃疡性结肠炎：与白细胞介素-10 和半乳糖凝集素-3 表达的相关性。
World J Gastroenterol. 2019 Nov 21;25(43):6465-6482. doi: 10.3748/wjg.v25.i43.6465.
2
Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis.肿瘤坏死因子-α的组织水平与未经治疗的溃疡性结肠炎的炎症程度相关。
Scand J Gastroenterol. 2007 Nov;42(11):1312-20. doi: 10.1080/00365520701409035.
3
Increased Severity of Ulcerative Colitis in the Terminal Phase of the Metabolic Syndrome.代谢综合征终末期溃疡性结肠炎严重程度增加。
Tohoku J Exp Med. 2021 Jul;254(3):171-182. doi: 10.1620/tjem.254.171.
4
KFL2 participates in the development of ulcerative colitis through inhibiting inflammation via regulating cytokines.KFL2 通过调节细胞因子抑制炎症参与溃疡性结肠炎的发生发展。
Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4941-4948. doi: 10.26355/eurrev_201808_15633.
5
Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis.活动性溃疡性结肠炎患者黏膜T细胞中白细胞介素10的过度表达。
Clin Exp Immunol. 2003 Oct;134(1):127-37. doi: 10.1046/j.1365-2249.2003.02268.x.
6
High Serum sCD40 and a Distinct Colonic T Cell Profile in Ulcerative Colitis Associated With Primary Sclerosing Cholangitis.血清 sCD40 水平升高与原发性硬化性胆管炎相关的溃疡性结肠炎的结肠 T 细胞特征明显不同。
J Crohns Colitis. 2019 Mar 26;13(3):341-350. doi: 10.1093/ecco-jcc/jjy170.
7
Local and systemic liberation of proinflammatory cytokines in ulcerative colitis.溃疡性结肠炎中促炎细胞因子的局部和全身释放
Dig Dis Sci. 1999 Apr;44(4):830-5. doi: 10.1023/a:1026690631693.
8
[Influence of moxibustion with different duration on colonic epithelial structure, serum inflammatory cytokines, and intestinal mucosa inflammatory cell signal transduction pathways].[不同时长艾灸对结肠上皮结构、血清炎性细胞因子及肠黏膜炎性细胞信号转导通路的影响]
Zhen Ci Yan Jiu. 2014 Feb;39(1):20-6.
9
MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis.黏膜相关恒定T细胞（MAIT细胞）在溃疡性结肠炎的炎症黏膜中被激活并积聚。
J Gastroenterol Hepatol. 2016 May;31(5):965-72. doi: 10.1111/jgh.13242.
10
Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis.白细胞介素-22/STAT3 信号通路在溃疡性结肠炎及其相关癌变中的表达。
World J Gastroenterol. 2013 May 7;19(17):2638-49. doi: 10.3748/wjg.v19.i17.2638.

引用本文的文献

1
IL-33 as a Marker of Poor Early Response in Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy.白细胞介素-33作为接受肽受体放射性核素治疗的神经内分泌肿瘤患者早期反应不佳的标志物。
Int J Mol Sci. 2025 Sep 2;26(17):8526. doi: 10.3390/ijms26178526.
2
Exploring the impact of galectins on liver cancer: From immunopathogenesis to potential targets.探索半乳糖凝集素对肝癌的影响：从免疫发病机制到潜在靶点。
World J Gastroenterol. 2025 Jul 7;31(25):107260. doi: 10.3748/wjg.v31.i25.107260.
3
Comprehensive Phytochemical Analysis and Evaluation of Antioxidant, Antimicrobial, Cytotoxic, and Immunomodulatory Activities of Commercial Cinnamon Bark Essential Oil ( L.).

本文引用的文献

1
Indoleamine 2,3-dioxygenase-dependent expansion of T-regulatory cells maintains mucosal healing in ulcerative colitis.吲哚胺2,3-双加氧酶依赖性调节性T细胞的扩增维持溃疡性结肠炎的黏膜愈合。
Therap Adv Gastroenterol. 2018 Aug 24;11:1756284818793558. doi: 10.1177/1756284818793558. eCollection 2018.
2
Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma.粪便半乳糖凝集素-3：结直肠癌严重程度和进展的新有前途的生物标志物。
Mediators Inflamm. 2018 Apr 4;2018:8031328. doi: 10.1155/2018/8031328. eCollection 2018.
3
Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients.
市售肉桂皮精油（L.）的综合植物化学分析及其抗氧化、抗菌、细胞毒性和免疫调节活性评估
Int J Mol Sci. 2025 Jul 5;26(13):6482. doi: 10.3390/ijms26136482.
4
Galectin-3-Insights from Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.半乳糖凝集素-3——来自炎症性肠病和原发性硬化性胆管炎的见解
Int J Mol Sci. 2025 Jun 25;26(13):6101. doi: 10.3390/ijms26136101.
5
Cardiometabolic diseases in patients with inflammatory bowel disease: An evidence-based review.炎症性肠病患者的心脏代谢疾病：一项循证综述。
World J Gastroenterol. 2025 Jun 28;31(24):107661. doi: 10.3748/wjg.v31.i24.107661.
6
Tumor-secreted galectin-3 suppresses antitumor response by inducing IL-10 B cells.肿瘤分泌的半乳糖凝集素-3通过诱导白细胞介素-10 B细胞来抑制抗肿瘤反应。
J Immunother Cancer. 2025 May 31;13(5):e011445. doi: 10.1136/jitc-2024-011445.
7
Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a meta-analysis on a global scale.炎症性肠病患者代谢综合征的患病率：一项全球范围的荟萃分析
J Health Popul Nutr. 2025 Apr 9;44(1):112. doi: 10.1186/s41043-025-00860-z.
8
Serum Galectin-3 as a Non-Invasive Marker for Primary Sclerosing Cholangitis.血清半乳糖凝集素-3 作为原发性硬化性胆管炎的非侵入性标志物。
Int J Mol Sci. 2024 Apr 27;25(9):4765. doi: 10.3390/ijms25094765.
9
Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a systematic review and meta-analysis.炎症性肠病患者代谢综合征的患病率：系统评价和荟萃分析。
BMJ Open. 2024 Mar 7;14(3):e074659. doi: 10.1136/bmjopen-2023-074659.
10
Fecal and Urinary Adipokines as Disease Biomarkers.粪便和尿液中的脂肪因子作为疾病生物标志物
Biomedicines. 2023 Apr 16;11(4):1186. doi: 10.3390/biomedicines11041186.
半乳糖凝集素-3在终末期肾病患者丙型肝炎病毒感染期间的潜在肝脏保护作用
Dis Markers. 2017;2017:6275987. doi: 10.1155/2017/6275987. Epub 2017 Apr 11.
4
Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.第三届欧洲溃疡性结肠炎诊断与管理循证共识。第1部分：定义、诊断、肠外表现、妊娠、癌症监测、手术及回肠储袋疾病
J Crohns Colitis. 2017 Jun 1;11(6):649-670. doi: 10.1093/ecco-jcc/jjx008.
5
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.造血来源的半乳糖凝集素-3导致细胞和全身性胰岛素抵抗。
Cell. 2016 Nov 3;167(4):973-984.e12. doi: 10.1016/j.cell.2016.10.025.
6
T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.T 细胞激活蛋白（T-bet）是肠道中白细胞介素-23（IL-23）驱动致病性 CD4+T 细胞应答的关键调节因子。
Nat Commun. 2016 May 19;7:11627. doi: 10.1038/ncomms11627.
7
Deletion of Galectin-3 Enhances Xenobiotic Induced Murine Primary Biliary Cholangitis by Facilitating Apoptosis of BECs and Release of Autoantigens.半乳糖凝集素-3的缺失通过促进胆管上皮细胞凋亡和自身抗原释放增强外源性诱导的小鼠原发性胆汁性胆管炎。
Sci Rep. 2016 Mar 21;6:23348. doi: 10.1038/srep23348.
8
Galectin-3 Plays an Important Pro-inflammatory Role in the Induction Phase of Acute Colitis by Promoting Activation of NLRP3 Inflammasome and Production of IL-1β in Macrophages.半乳糖凝集素-3通过促进巨噬细胞中NLRP3炎性小体的激活和白细胞介素-1β的产生，在急性结肠炎的诱导期发挥重要的促炎作用。
J Crohns Colitis. 2016 May;10(5):593-606. doi: 10.1093/ecco-jcc/jjw013. Epub 2016 Jan 19.
9
Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis.半乳糖凝集素-3可抑制实验性结肠炎中的黏膜炎症并减轻疾病严重程度。
J Mol Med (Berl). 2016 May;94(5):545-56. doi: 10.1007/s00109-015-1368-x. Epub 2015 Dec 2.
10
Glucose intolerance and diabetes mellitus in ulcerative colitis: pathogenetic and therapeutic implications.溃疡性结肠炎中的葡萄糖不耐受和糖尿病：发病机制及治疗意义
World J Gastroenterol. 2014 Apr 7;20(13):3507-15. doi: 10.3748/wjg.v20.i13.3507.