Evan Goldhagen Brian, Goldhardt Raquel
Miami Veterans Administration Medical Center, 1201 NW 16th St, Miami, FL 33125.
Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 NW 17 Street, Miami, FL, 33136.
Curr Ophthalmol Rep. 2019 Jun;7(2):73-79. doi: 10.1007/s40135-019-00202-3. Epub 2019 Apr 16.
This is a comprehensive review of management options for retinal arterial macroaneurysms (RAMs). Although close observation is typically recommended for RAMs not involving or threatening the macula, other treatment modalities can be considered for exudative or hemorrhagic complications that are vision-threatening.
New imaging technologies like optical coherence tomography angiography (OCT-A) have been able to detect RAMs without the need of dye injection, further elucidating our understanding of blood flow within and around them. Observation alone is usually adequate treatment when lesion not threatening the fovea. Laser photocoagulation and intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors have effectively been used for management of exudative RAMs, whereas options including injection of VEGF inhibitors, tissue plasminogen activator (tPA), vitrectomy, gas, and yttrium aluminum garnet (YAG) laser have been used for hemorrhagic RAMs.
To date, there is no consensus regarding management of symptomatic exudative or hemorrhagic complications of RAM. Additionally, a case report is presented within this paper to illustrate the successful treatment of a hemorrhagic RAM in a symptomatic 65-year-old man using intravitreal bevacizumab.
本文全面回顾了视网膜动脉大动脉瘤(RAM)的治疗选择。对于不涉及或不威胁黄斑的RAM,通常建议密切观察,但对于有视力威胁的渗出性或出血性并发症,可考虑其他治疗方式。
光学相干断层扫描血管造影(OCT-A)等新成像技术无需注射染料就能检测到RAM,进一步加深了我们对其内部及周围血流的理解。当病变不威胁黄斑中心凹时,单纯观察通常是足够的治疗方法。激光光凝和玻璃体内注射血管内皮生长因子(VEGF)抑制剂已有效地用于治疗渗出性RAM,而包括注射VEGF抑制剂、组织纤溶酶原激活剂(tPA)、玻璃体切除术、气体和钇铝石榴石(YAG)激光等方法已用于治疗出血性RAM。
迄今为止,对于RAM有症状的渗出性或出血性并发症的治疗尚无共识。此外,本文还介绍了一例病例报告,展示了玻璃体内注射贝伐单抗成功治疗一名有症状的65岁男性出血性RAM的情况。