Penadés Rafael, Bosia Marta, Catalán Rosa, Spangaro Marco, García-Rizo Clemente, Amoretti Silvia, Bioque Miquel, Bernardo Miquel
Barcelona Clinic Schizophrenia Unit, Hospital Clinic Barcelona, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Schizophr Res Cogn. 2019 May 1;19:100146. doi: 10.1016/j.scog.2019.100146. eCollection 2020 Mar.
The role of genetics in cognitive remediation therapies in schizophrenia has not been completely understood yet. Different genes involved in neurotrophic, dopaminergic and serotonin systems have reported to influence cognitive functioning in schizophrenia. These genetic factors could also be contributing to the variability in responsiveness to cognitive treatments. No comprehensive synthesis of the literature of the role of genetics in the context of cognitive remediation has been conducted until now. We aimed to systematically review the published works through three electronic database searches: PubMed, Scopus, and the Cochrane Library. Eligible studies revealed a rising interest in the field although the number of published studies was rather small (n = 10). Eventually, promising results showing a relationship between some phenotypic variations based on different polymorphisms and different levels of responsivity to cognitive remediation therapies have been described although results are still inconclusive. In case those findings will be replicated, they could be guiding future research and informing clinical decision-making in the next future.
遗传学在精神分裂症认知康复治疗中的作用尚未完全明确。据报道，神经营养、多巴胺能和5-羟色胺系统中涉及的不同基因会影响精神分裂症的认知功能。这些遗传因素也可能导致认知治疗反应的变异性。到目前为止，尚未对遗传学在认知康复背景下的作用进行全面的文献综述。我们旨在通过三个电子数据库搜索（PubMed、Scopus和Cochrane图书馆）对已发表的作品进行系统综述。符合条件的研究表明，尽管已发表的研究数量相当少（n = 10），但该领域的关注度在不断上升。最终，尽管结果仍无定论，但已描述了一些基于不同多态性的表型变异与对认知康复治疗的不同反应水平之间关系的有前景的结果。如果这些发现能够得到重复验证，它们可能会指导未来的研究，并为未来的临床决策提供参考。
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