Department of Bioengineering, McGill University, Montreal, Quebec, Canada.
Analyst. 2020 Jan 21;145(2):364-384. doi: 10.1039/c9an02149c. Epub 2019 Dec 13.
Plasmonics has drawn significant attention in the area of biosensors for decades due to the unique optical properties of plasmonic resonant nanostructures. While the sensitivity and specificity of molecular detection relies significantly on the resonance conditions, significant attention has been dedicated to the design, fabrication, and optimization of plasmonic substrates. The adequate choice of materials, structures, and functionality goes hand in hand with a fundamental understanding of plasmonics to enable the development of practical biosensors that can be deployed in real life situations. Here we provide a brief review of plasmonic biosensors detailing most recent developments and applications. Besides metals, novel plasmonic materials such as graphene are highlighted. Sensors based on Surface Plasmon Resonance (SPR), Localized Surface Plasmon Resonance (LSPR), and Surface Enhanced Raman Spectroscopy (SERS) are presented and classified based on their materials and structure. In addition, most recent applications to environment monitoring, health diagnosis, and food safety are presented. Potential problems related to the implementation in such applications are discussed and an outlook is presented.
等离子体学在生物传感器领域引起了数十年的关注，这是由于等离子体共振纳米结构的独特光学特性。虽然分子检测的灵敏度和特异性很大程度上取决于共振条件，但人们对等离子体基底的设计、制造和优化给予了极大的关注。适当选择材料、结构和功能与对等离子体学的基本理解息息相关，这使得能够开发出可在实际生活场景中部署的实用生物传感器。在这里，我们简要回顾了等离子体生物传感器，详细介绍了最新的发展和应用。除了金属，我们还强调了新型等离子体材料，如石墨烯。介绍了基于表面等离子体共振（SPR）、局域表面等离子体共振（LSPR）和表面增强拉曼光谱（SERS）的传感器，并根据其材料和结构进行了分类。此外，还介绍了最近在环境监测、健康诊断和食品安全方面的应用。讨论了在这些应用中实施相关的潜在问题，并提出了展望。
