Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
Gut Liver. 2020 Sep 15;14(5):644-651. doi: 10.5009/gnl19272.
BACKGROUND/AIMS: This study aimed to investigate the epidemiology of hepatitis C virus (HCV) infection in the Korean general population and the awareness and treatment status of HCV infection among anti-HCV-positive persons.
We used data from the Korea National Health and Nutrition Examination Survey (KNHNES) collected between 2012 and 2016. All the participants aged ≥10 years in the KNHNES were tested for the anti-HCV antibody. Anti-HCV-positive persons were tested for HCV RNA and assessed for their awareness and treatment experience regarding HCV infection.
The prevalence of anti-HCV was 0.66% (95% confidence interval, 0.56% to 0.78%) among Koreans aged ≥10 years, representing an estimated 278,819 anti-HCV-positive persons, and 0.71% (95% confidence interval, 0.60% to 0.84%) among Koreans aged ≥20 years. The prevalence of anti-HCV increased with age and had significant geographic variation. The positive rate of HCV RNA in anti-HCV-positive persons was 33.5% and increased with age. The rate of HCV infection awareness was 15.2% (35/250) among anti- HCV-positive persons and 30.5% (18/59) among HCV RNApositive persons. Among the participants, 13.5% of HCV RNA-positive persons had been treated for HCV infection.
The prevalence of anti-HCV among Koreans aged ≥20 years was 0.71%; one-third of anti-HCV-positive persons tested HCV RNA-positive. The awareness and treatment rates of HCV infection were low among HCV-infected persons. Therefore, active measures should be taken to diagnose and treat persons unaware of HCV infection.
背景/目的：本研究旨在调查韩国普通人群中丙型肝炎病毒（HCV）感染的流行病学情况，以及抗-HCV 阳性者对 HCV 感染的知晓和治疗状况。
我们使用了 2012 年至 2016 年期间韩国国家健康和营养检查调查（KNHNES）的数据。KNHNES 中所有年龄≥10 岁的参与者都接受了抗-HCV 抗体检测。抗-HCV 阳性者接受了 HCV RNA 检测，并评估了他们对 HCV 感染的知晓和治疗经验。
年龄≥10 岁的韩国人中抗-HCV 的流行率为 0.66%（95%置信区间，0.56%至 0.78%），估计有 278819 名抗-HCV 阳性者，年龄≥20 岁的韩国人中抗-HCV 的流行率为 0.71%（95%置信区间，0.60%至 0.84%）。抗-HCV 的流行率随年龄增长而增加，且具有显著的地域差异。抗-HCV 阳性者中 HCV RNA 的阳性率为 33.5%，并随年龄增长而增加。抗-HCV 阳性者中 HCV 感染的知晓率为 15.2%（35/250），HCV RNA 阳性者中为 30.5%（18/59）。在参与者中，13.5%的 HCV RNA 阳性者接受了 HCV 感染的治疗。
年龄≥20 岁的韩国人中抗-HCV 的流行率为 0.71%；三分之一的抗-HCV 阳性者检测 HCV RNA 阳性。HCV 感染者中 HCV 感染的知晓率和治疗率较低。因此，应采取积极措施诊断和治疗未意识到 HCV 感染的人群。
