Department of Medicine, University of Connecticut, Farmington, CT, USA.
The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Nat Commun. 2019 Dec 16;10(1):5714. doi: 10.1038/s41467-019-13698-x.
The airway microbiome has an important role in asthma pathophysiology. However, little is known on the relationships between the airway microbiome of asthmatic children, loss of asthma control, and severe exacerbations. Here we report that the microbiota's dynamic patterns and compositions are related to asthma exacerbations. We collected nasal blow samples (n = 319) longitudinally during a clinical trial at 2 time-points within one year: randomization when asthma is under control, and at time of early loss of asthma control (yellow zone (YZ)). We report that participants whose microbiota was dominated by the commensal Corynebacterium + Dolosigranulum cluster at RD experience the lowest rates of YZs (p = 0.005) and have longer time to develop at least 2 episodes of YZ (p = 0.03). The airway microbiota have changed from randomization to YZ. A switch from the Corynebacterium + Dolosigranulum cluster at randomization to the Moraxella- cluster at YZ poses the highest risk of severe asthma exacerbation (p = 0.04). Corynebacterium's relative abundance at YZ is inversely associated with severe exacerbation (p = 0.002).
气道微生物组在哮喘发病机制中具有重要作用。然而，对于哮喘儿童的气道微生物组、哮喘控制丧失和严重恶化之间的关系，人们知之甚少。在这里，我们报告说，微生物组的动态模式和组成与哮喘恶化有关。我们在一年内的 2 个时间点收集了鼻吹气样本（n=319）：在哮喘得到控制时进行随机分组，以及在哮喘控制早期丧失时（黄色区域（YZ））。我们报告说，在 RD 时，其微生物组被共生棒状杆菌+小球菌簇主导的参与者经历 YZ 的最低率（p=0.005），并且发展至少 2 次 YZ 的时间更长（p=0.03）。气道微生物群从随机分组到 YZ 已经发生了变化。从随机分组时的棒状杆菌+小球菌簇到 YZ 时的莫拉氏菌簇的转变，是严重哮喘恶化的最高风险（p=0.04）。YZ 时棒状杆菌的相对丰度与严重恶化呈负相关（p=0.002）。
