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本文引用的文献

1
Development of high throughput, high precision synthesis platforms and characterization methodologies for toxicological studies of nanocellulose.用于纳米纤维素毒理学研究的高通量、高精度合成平台及表征方法的开发。
Cellulose (Lond). 2018 Mar 3;25:2303-2319.
2
Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.基于功能化的纤维素纳米纤维对人树突状细胞耐受机制的影响。
Int J Nanomedicine. 2018 Oct 31;13:6941-6960. doi: 10.2147/IJN.S183510. eCollection 2018.
3
Fluorescently Labelled Silica Coated Gold Nanoparticles as Fiducial Markers for Correlative Light and Electron Microscopy.荧光标记的硅涂层金纳米颗粒作为光镜和电镜相关研究的基准标记物。
Sci Rep. 2018 Sep 11;8(1):13625. doi: 10.1038/s41598-018-31836-1.
4
Reducing Intestinal Digestion and Absorption of Fat Using a Nature-Derived Biopolymer: Interference of Triglyceride Hydrolysis by Nanocellulose.利用天然生物聚合物减少脂肪的肠道消化和吸收：纳米纤维素对甘油三酯水解的干扰。
ACS Nano. 2018 Jul 24;12(7):6469-6479. doi: 10.1021/acsnano.8b03074. Epub 2018 Jun 12.
5
Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month.纳米原纤纤维素可导致急性肺部炎症，该炎症在一个月内消退。
Nanotoxicology. 2018 Sep;12(7):729-746. doi: 10.1080/17435390.2018.1472312. Epub 2018 May 30.
6
Multi-level toxicity assessment of engineered cellulose nanofibrils in Daphnia magna.大型溞体内工程化纤维素纳米纤维的多层次毒性评估。
Nanotoxicology. 2018 Aug;12(6):509-521. doi: 10.1080/17435390.2018.1464229. Epub 2018 May 6.
7
The Role of the Food Matrix and Gastrointestinal Tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and knowledge gaps.食物基质和胃肠道在评估摄入的工程纳米材料（iENMs）生物学特性中的作用：科学现状与知识差距
NanoImpact. 2016 Jul;3-4:47-57. doi: 10.1016/j.impact.2016.10.002. Epub 2016 Oct 13.
8
Fibrous nanocellulose, crystalline nanocellulose, carbon nanotubes, and crocidolite asbestos elicit disparate immune responses upon pharyngeal aspiration in mice.在经口吸入后，纤维纳米纤维素、结晶纳米纤维素、碳纳米管和青石棉在小鼠中引发不同的免疫反应。
J Immunotoxicol. 2018 Dec;15(1):12-23. doi: 10.1080/1547691X.2017.1414339.
9
Effect of surface organic coatings of cellulose nanocrystals on the viability of mammalian cell lines.纤维素纳米晶体表面有机涂层对哺乳动物细胞系活力的影响。
Nanotechnol Sci Appl. 2017 Sep 28;10:123-136. doi: 10.2147/NSA.S145891. eCollection 2017.
10
An integrated methodology for assessing the impact of food matrix and gastrointestinal effects on the biokinetics and cellular toxicity of ingested engineered nanomaterials.一种综合方法，用于评估食物基质和胃肠道效应对摄入的工程纳米材料生物动力学和细胞毒性的影响。
Part Fibre Toxicol. 2017 Oct 13;14(1):40. doi: 10.1186/s12989-017-0221-5.

用于纳米毒理学研究的荧光标记纳米纤维素的开发与表征

Development & Characterization of Fluorescently Tagged Nanocellulose for Nanotoxicological Studies.

作者信息

Salari Maryam, Bitounis Dimitrios, Bhattacharya Kunal, Pyrgiotakis Georgios, Zhang Zhenyuan, Purington Emilia, Gramlich William, Grondin Yohann, Rogers Rick, Bousfield Douglas, Demokritou Philip

机构信息

Center for Nanotechnology and Nanotoxicology, Harvard T. H. Chan School of Public Health, Boston, MA, 07016, USA.

Department of Chemical and Biological Engineering, University of Maine, Orono ME 04469 USA.

出版信息

Environ Sci Nano. 2019 May 1;6(5):1516-1526. doi: 10.1039/C8EN01381K. Epub 2019 Apr 10.

DOI:10.1039/C8EN01381K
PMID:31844523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6914317/
Abstract

The rapid adoption of nanocellulose-based engineered nanomaterials (CNM) by many industries generates environmental health and safety (EHS) concerns. This work presents the development of fluorescently tagged CNM which can be used to study their interactions with biological systems. Specifically, cellulose nano-fibrils and cellulose nano-crystals with covalently attached fluorescein isothiocyanate (FITC) molecules on their surface were synthesized. The fluorescence of the FITC-tagged materials was assessed along with potential FITC detachment under pH conditions encountered in the human gastrointestinal tract, in intracellular compartments, and in cell culture media. Finally, the potential cytotoxicity due to the presence of FITC molecules on the surface of CNM was assessed using a cellular gut epithelium model. The results showed that neither FITC-CNF nor FITC-CNC were cytotoxic and that they have a comparable bioactivity to their untagged counterparts, rendering them suitable for biological studies.

摘要

许多行业对基于纳米纤维素的工程纳米材料（CNM）的迅速采用引发了环境健康与安全（EHS）方面的担忧。这项工作展示了荧光标记的CNM的开发，其可用于研究它们与生物系统的相互作用。具体而言，合成了表面共价连接有异硫氰酸荧光素（FITC）分子的纤维素纳米纤维和纤维素纳米晶体。评估了FITC标记材料的荧光以及在人类胃肠道、细胞内区室和细胞培养基中遇到的pH条件下FITC的潜在脱离情况。最后，使用细胞肠道上皮模型评估了由于CNM表面存在FITC分子而导致的潜在细胞毒性。结果表明，FITC-CNF和FITC-CNC均无细胞毒性，并且它们与其未标记的对应物具有相当的生物活性，使其适用于生物学研究。