Department of Cancer Biology, Institute of Biology, Warsaw University of Life Sciences - SGGW, Warsaw, Poland.
Department of Immunology, Centre for Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
J Physiol Pharmacol. 2019 Oct;70(5). doi: 10.26402/jpp.2019.5.03. Epub 2019 Dec 26.
Currently, many therapies fail due to an insufficient drug dose reaching the target site and high systemic toxicity. Protein-based drug delivery systems that allow an increase in drug concentration at a specific location in the body or predominantly target malignant cells are promising technologies. Due to the high need for iron in many disorders including various types of cancer, iron-binding proteins: transferrin, ferritin and hemoglobin, are a promising tool as drug carriers. In this review we summarize the characteristics of human iron-binding proteins and present their use in targeted drug delivery strategies.
目前，由于到达靶位的药物剂量不足和全身毒性高，许多疗法都失败了。蛋白质药物递送系统可增加体内特定部位的药物浓度，或主要靶向恶性细胞，是很有前途的技术。由于许多疾病（包括各种类型的癌症）都对铁有很高的需求，因此铁结合蛋白（转铁蛋白、铁蛋白和血红蛋白）是一种很有前途的药物载体。在这篇综述中，我们总结了人类铁结合蛋白的特性，并介绍了它们在靶向药物递送策略中的应用。
