Ferraz E M, Gray R H, Fleming P L, Maia T M
University of Brasilia, Department of Obstetrics and Gynecology, Brazil.
Am J Epidemiol. 1988 Nov;128(5):1111-6. doi: 10.1093/oxfordjournals.aje.a115053.
In a case-control study in Natal, northeast Brazil, conducted between September 1984 and February 1986, 303 cases of intrauterine growth retardation and 282 cases of preterm delivery were compared with 1,710 normal controls to ascertain the effects of the preceding birth-to-conception interval on pregnancy outcome. The risk of intrauterine growth retardation associated with interpregnancy intervals of six months or less was 1.38 (95% confidence interval (CI): 1.02-1.86) after adjustment for maternal age, education, smoking, and prior fetal loss or low birth weight. When maternal postpartum body weight was introduced into the logistic model, the risk of intrauterine growth retardation decreased slightly to 1.25 and was no longer significant (95% CI: 0.91-1.72). Short interpregnancy intervals (six months or less) were more frequently observed in women with postpartum body weight of less than 45 kg (31.1%) than in women weighing 50 kg or more (18.9%), which might suggest that the effect of short intervals on the risk of intrauterine growth retardation is mediated through maternal nutritional status. No association was found between birth-to-conception intervals and preterm delivery.
在1984年9月至1986年2月于巴西东北部纳塔尔开展的一项病例对照研究中，将303例宫内生长受限病例和282例早产病例与1710例正常对照进行比较，以确定上次分娩至受孕间隔对妊娠结局的影响。在对产妇年龄、教育程度、吸烟情况以及既往胎儿丢失或低出生体重进行校正后，妊娠间隔为6个月或更短时间与宫内生长受限相关的风险为1.38（95%置信区间（CI）：1.02 - 1.86）。当将产妇产后体重纳入逻辑模型时，宫内生长受限的风险略有下降至1.25，且不再具有统计学意义（95% CI：0.91 - 1.72）。产后体重低于45 kg的女性中，妊娠间隔短（6个月或更短）的情况比体重50 kg或更高的女性更为常见（31.1% 对比18.9%），这可能表明短间隔对宫内生长受限风险的影响是通过产妇营养状况介导的。未发现分娩至受孕间隔与早产之间存在关联。
