反应谱：一种评估β-内酰胺类抗生素对肠杆菌活性的方法。
Response profiles: A method of evaluating the activity of beta-lactam antibiotics against Enterobacteria.
作者信息
Greenwood D
出版信息
Chemotherapy. 1977;23(1):11-8. doi: 10.1159/000221965.
A method is described which may be used to compare the relative activity of beta-lactam antibiotics against gram-negative bacilli. The method offers several important advantages over conventional methods of evaluation of the antibacterial activity of beta-lactam agents: the bacterial inoculum is simply and accurately standardized; the response of the culture is continuously monitored and information is obtained on both the intrinsic activity of the agent and its susceptibility to enterobacterial beta-lactamases. In this way, differences in the antibacterial activity of compounds which appear similar on the basis of more conventional tests may be revealed.
本文描述了一种可用于比较β-内酰胺类抗生素对革兰氏阴性杆菌相对活性的方法。与评估β-内酰胺类药物抗菌活性的传统方法相比，该方法具有几个重要优点：细菌接种量简单且准确地标准化；对培养物的反应进行持续监测，并获得有关药物内在活性及其对肠杆菌β-内酰胺酶敏感性的信息。通过这种方式，可以揭示在更传统测试中看似相似的化合物在抗菌活性方面的差异。
Zotero 插件