Department of Orthopedics, the First People's Hospital of Changzhou, Soochow University Medical College, Changzhou, 213003, Jiangsu, China.
Arch Osteoporos. 2020 Jan 2;15(1):5. doi: 10.1007/s11657-019-0677-z.
Angiogenesis in the bone and its role in bone metabolic plays a fundamental role in the pathology of osteoporosis. Type-H vessels have been reported to exhibit distinct morphological, molecular, and functional properties. This review is aimed to illustrate the relationship between type-H vessels in the bone and bone metabolism.
This manuscript reviews the articles on in vitro and in vivo experiments concerning the topic of type-H vessels and osteoporosis, and other researches in the area published by the author within the time frame from 2014 to 2019.
Current literatures have demonstrated that age-related loss of type-H vessels plays a critical role in the pathogenesis of osteoporosis. Impaired bone mass can be reserved by enhancing the formation of type-H vessels. Activation of the Notch and Hif-1α signaling pathway in bone tissue and exogenous PDGF-BB treatment increase the number of type-H vessels, along with the restoration of bone mass. The effects of osteoblasts and low-intensity pulsed ultrasound (LIPUS) on type-H vessels remain to be further studied.
These studies support unique functions for type-H vessels in the bone that may enable new therapeutic approaches to osteoporosis.
骨骼中的血管生成及其在骨代谢中的作用在骨质疏松症的病理学中起着至关重要的作用。已经报道了 H 型血管具有独特的形态、分子和功能特性。本综述旨在阐明骨骼中的 H 型血管与骨代谢之间的关系。
本文综述了作者在 2014 年至 2019 年期间发表的关于 H 型血管和骨质疏松症的体外和体内实验的文章，以及该领域的其他研究。
目前的文献表明，与年龄相关的 H 型血管的丧失在骨质疏松症的发病机制中起着关键作用。通过增强 H 型血管的形成可以保留受损的骨量。骨组织中 Notch 和 Hif-1α信号通路的激活以及外源性 PDGF-BB 治疗增加了 H 型血管的数量，同时恢复了骨量。成骨细胞和低强度脉冲超声（LIPUS）对 H 型血管的影响仍需进一步研究。
这些研究支持 H 型血管在骨骼中具有独特的功能，这可能为骨质疏松症提供新的治疗方法。
