两种源自海绵的新型芳香族聚酮化合物。
Two new aromatic polyketides from a sponge-derived .
作者信息
Sibero Mada Triandala, Zhou Tao, Fukaya Keisuke, Urabe Daisuke, Radjasa Ocky K Karna, Sabdono Agus, Trianto Agus, Igarashi Yasuhiro
机构信息
Department of Marine Science, Faculty of Fisheries and Marine Science, Diponegoro University, Tembalang Campus, St. Prof. Soedarto SH, Semarang, 50275 Central Java, Indonesia.
Marine Science Techno Park, Diponegoro University, Teluk Awur Campus, St. Undip, Jepara District, Central Java, Indonesia.
出版信息
Beilstein J Org Chem. 2019 Dec 9;15:2941-2947. doi: 10.3762/bjoc.15.289. eCollection 2019.
In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A () and B () and five known compounds (-) were isolated from sponge-associated sp. KJMT.FP.4.3 which was collected from an Indonesian sponge sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of was assisted by DFT-based theoretical chemical shift calculation. Compound showed antibacterial activity against multidrug resistant ser. Typhi with a MIC of 125 µg/mL while was not active.
在我们从海洋真菌中进行的天然产物筛选项目中，从与海绵相关的KJMT.FP.4.3菌株中分离出了两种新的芳香聚酮化合物卡里蒙酮A（）和B（）以及五种已知化合物（-），该菌株是从印度尼西亚海绵物种中采集的。通过对核磁共振（NMR）和质谱（MS）光谱数据的分析确定了这些化合物的结构。通过基于密度泛函理论（DFT）的理论化学位移计算辅助了对的核磁共振归属。化合物对多重耐药伤寒杆菌血清型表现出抗菌活性，最低抑菌浓度（MIC）为125微克/毫升，而没有活性。
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