Corrêa Telma Angelina Faraldo, Rogero Marcelo Macedo, Hassimotto Neuza Mariko Aymoto, Lajolo Franco Maria
Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Food Research Center, CEPID-FAPESP (Research Innovation and Dissemination Centers, São Paulo Research Foundation), São Paulo, Brazil.
Front Nutr. 2019 Dec 20;6:188. doi: 10.3389/fnut.2019.00188. eCollection 2019.
Metabolic diseases can change the gut microbiota composition and function, and pathogenic bacteria contribute to the development of metabolic disorders. Polyphenols may act in the gut microbiota to favor the increase of beneficial bacteria and hamper the increase of pathogenic bacteria. In addition, the microbiota may act on polyphenols to increase their bioavailability. This two-way interactions between polyphenols and the gut microbiota could affect human metabolism and reduce cardiometabolic risk. Despite the possible benefits of polyphenols for human health through modulating the microbiome, studies are scarce, and present several limitations. This review provides an overview of the polyphenol-microbiota interactions and its effects on metabolic disorders.
代谢性疾病会改变肠道微生物群的组成和功能，而病原菌会导致代谢紊乱的发生。多酚可能作用于肠道微生物群，有利于有益菌的增加并抑制病原菌的增加。此外，微生物群可能作用于多酚以提高其生物利用度。多酚与肠道微生物群之间的这种双向相互作用可能会影响人体代谢并降低心血管代谢风险。尽管多酚通过调节微生物群可能对人类健康有益，但相关研究较少，且存在一些局限性。本综述概述了多酚与微生物群的相互作用及其对代谢紊乱的影响。
