School of Life Sciences, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, China.
Khoury College of Computer Sciences, Northeastern University, Seattle, 98109, WA, USA.
Sci Rep. 2020 Jan 10;10(1):149. doi: 10.1038/s41598-019-57038-x.
Sliding window analysis has been extensively applied in evolutionary biology. With the development of the high-throughput DNA sequencing of organisms at the population level, an application that is dedicated to visualizing population genetic test statistics at the genomic level is needed. We have developed the sliding window analysis viewer (SWAV), which is a web-based program that can be used to integrate, view and browse test statistics and perform genome annotation. In addition to browsing, SAV can mark, generate and customize statistical images and search by sequence alignment, position or gene name. These features facilitate the effectiveness of sliding window analysis. As an example application, yeast and silkworm resequencing data are analyzed with SWAV. The SWAV package, user manual and usage demo are available at http://swav.popgenetics.net.
滑动窗口分析在进化生物学中得到了广泛应用。随着高通量 DNA 测序技术在群体水平上对生物体的发展，需要有一种专门用于在基因组水平上可视化群体遗传检验统计的应用程序。我们开发了滑动窗口分析查看器 (SWAV)，这是一个基于网络的程序，可以用于整合、查看和浏览检验统计数据，并进行基因组注释。除了浏览之外，SWAV 还可以标记、生成和自定义统计图像，并通过序列比对、位置或基因名称进行搜索。这些功能提高了滑动窗口分析的效率。作为一个示例应用，我们使用 SWAV 分析了酵母和家蚕重测序数据。SWAV 包、用户手册和使用演示可在 http://swav.popgenetics.net 上获得。
