大肠杆菌λ溶原菌的繁殖适应性增强。
Increased reproductive fitness of Escherichia coli lambda lysogens.
作者信息
Lin L, Bitner R, Edlin G
出版信息
J Virol. 1977 Feb;21(2):554-9. doi: 10.1128/JVI.21.2.554-559.1977.
Abstract
Lambda lysogens of Escherichia coli reproduce more rapidly than nonlysogens during aerobic growth in glucose-limited chemostats. If the environment is changed to anaerobic growth, the situation is reversed, and the lysogen reproduces more slowly than the nonlysogen. Based on a tetrazolium dye assay, the increased fitness of the lambda lysogen during aerobic growth seems to result from a continued high metabolic rate as glucose becomes limiting, whereas the metabolic rate of the nonlysogen declines. The lambda rex gene is required for the growth advantage of lysogens since lack of rex function causes lambda lysogens to lose their reproductive advantage over nonlysogens.
摘要
在葡萄糖受限的恒化器中进行需氧生长时，大肠杆菌的λ溶原菌比非溶原菌繁殖得更快。如果环境变为厌氧生长，情况则相反，溶原菌比非溶原菌繁殖得更慢。基于四氮唑染料测定法，λ溶原菌在需氧生长期间适应性增强似乎是由于随着葡萄糖变得有限，其代谢率持续保持在较高水平，而非溶原菌的代谢率则下降。λ溶原菌的生长优势需要λ rex基因，因为缺乏rex功能会导致λ溶原菌失去相对于非溶原菌的繁殖优势。
相似文献
1
Increased reproductive fitness of Escherichia coli lambda lysogens.大肠杆菌λ溶原菌的繁殖适应性增强。
J Virol. 1977 Feb;21(2):554-9. doi: 10.1128/JVI.21.2.554-559.1977.
2
Reproductive fitness of P1, P2, and Mu lysogens of Escherichia coli.大肠杆菌P1、P2和Mu溶原菌的生殖适应性。
J Virol. 1977 Feb;21(2):560-4. doi: 10.1128/JVI.21.2.560-564.1977.
3
Lambda lysogens of E. coli reproduce more rapidly than non-lysogens.大肠杆菌的λ溶原菌比非溶原菌繁殖得更快。
Nature. 1975 Jun 26;255(5511):735-7. doi: 10.1038/255735a0.
4
Regulation of lambda rex expression after infection of Escherichia coli K by lambda bacteriophage.λ噬菌体感染大肠杆菌K后λ rex表达的调控
J Virol. 1972 Mar;9(3):510-8. doi: 10.1128/JVI.9.3.510-518.1972.
5
The influences of a lambda prophage on the growth rate of Escherichia coli.λ原噬菌体对大肠杆菌生长速率的影响。
Microbios. 1978;23(92):99-113.
6
Heat-sensitive early function in induced lambda Nsus lysogens.诱导型λNsus溶原菌中的热敏感早期功能。
J Virol. 1970 Jul;6(1):33-41. doi: 10.1128/JVI.6.1.33-41.1970.
7
Analysis of the phase variation in lambda reduced immunity lysogens.
Mol Gen Genet. 1977 Mar 7;151(2):181-7. doi: 10.1007/BF00338693.
8
Reduced immunity in lysogens of bacteriophage lambda due to a mutation in the prophage.由于原噬菌体中的突变，噬菌体λ溶原菌的免疫力降低。
Virology. 1970 Nov;42(3):707-16. doi: 10.1016/0042-6822(70)90316-8.
9
Isolation and characterization of lambda pleu bacteriophages.λ 类噬菌体的分离与特性分析
J Bacteriol. 1977 Feb;129(2):1078-90. doi: 10.1128/jb.129.2.1078-1090.1977.
10
Interactions between the vegetative states of phages lambda and T1.噬菌体λ和T1营养态之间的相互作用。
J Virol. 1974 Dec;14(6):1430-4. doi: 10.1128/JVI.14.6.1430-1434.1974.
引用本文的文献
1
Evaluating phage lytic activity: from plaque assays to single-cell technologies.评估噬菌体裂解活性：从噬菌斑测定到单细胞技术。
Front Microbiol. 2025 Aug 29;16:1659093. doi: 10.3389/fmicb.2025.1659093. eCollection 2025.
2
Chemical-Biology and Metabolomics Studies in Phage-Host Interactions.噬菌体-宿主相互作用中的化学生物学和代谢组学研究。
Adv Exp Med Biol. 2023;1439:71-100. doi: 10.1007/978-3-031-41741-2_4.
3
Temperate Bacteriophages-The Powerful Indirect Modulators of Eukaryotic Cells and Immune Functions.温和噬菌体——真核细胞和免疫功能的强大间接调节剂。
Viruses. 2021 May 28;13(6):1013. doi: 10.3390/v13061013.
4
Elements in the λ immunity region regulate phage development: beyond the 'Genetic Switch'.λ 免疫区的元件调节噬菌体的发育：超越“遗传开关”。
Mol Microbiol. 2019 Dec;112(6):1798-1813. doi: 10.1111/mmi.14394. Epub 2019 Oct 8.
5
Horizontal gene transfer overrides mutation in colonizing the mammalian gut.水平基因转移在哺乳动物肠道定殖中超过了突变。
Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17906-17915. doi: 10.1073/pnas.1906958116. Epub 2019 Aug 20.
6
Shigatoxin encoding Bacteriophage ϕ24 modulates bacterial metabolism to raise antimicrobial tolerance.志贺毒素编码噬菌体 ϕ24 调节细菌代谢以提高抗菌药物耐受性。
Sci Rep. 2017 Jan 20;7:40424. doi: 10.1038/srep40424.
7
Carriage of λ Latent Virus Is Costly for Its Bacterial Host due to Frequent Reactivation in Monoxenic Mouse Intestine.由于在单菌小鼠肠道中频繁重新激活，λ潜伏病毒的携带对其细菌宿主来说成本高昂。
PLoS Genet. 2016 Feb 12;12(2):e1005861. doi: 10.1371/journal.pgen.1005861. eCollection 2016 Feb.
8
A new perspective on lysogeny: prophages as active regulatory switches of bacteria.一种关于溶原性的新视角：噬菌体作为细菌的活跃调控开关。
Nat Rev Microbiol. 2015 Oct;13(10):641-50. doi: 10.1038/nrmicro3527.
9
Environmental bacteriophages: viruses of microbes in aquatic ecosystems.环境噬菌体：水生生态系统中微生物的病毒。
Front Microbiol. 2014 Jul 24;5:355. doi: 10.3389/fmicb.2014.00355. eCollection 2014.
10
Transposable prophage Mu is organized as a stable chromosomal domain of E. coli.可转移的前噬菌体 Mu 组织为大肠杆菌染色体的稳定结构域。
PLoS Genet. 2013 Nov;9(11):e1003902. doi: 10.1371/journal.pgen.1003902. Epub 2013 Nov 7.
本文引用的文献
1
Temperate Bacteriophage Which Causes the Production of a New Major Outer Membrane Protein by Escherichia coli.导致大肠杆菌产生一种新的主要外膜蛋白的温和噬菌体。
J Virol. 1975 May;15(5):1121-30. doi: 10.1128/JVI.15.5.1121-1130.1975.
2
Effect of metabolic activity on the glucose permease of bacterial cells.代谢活性对细菌细胞葡萄糖通透酶的影响。
Proc Natl Acad Sci U S A. 1962 Oct 15;48(10):1759-65. doi: 10.1073/pnas.48.10.1759.
3
Bacterial permeases.细菌通透酶
Bacteriol Rev. 1957 Sep;21(3):169-94. doi: 10.1128/br.21.3.169-194.1957.
4
Lysogeny.溶源性
Bacteriol Rev. 1953 Dec;17(4):269-337. doi: 10.1128/br.17.4.269-337.1953.
5
Phage lambda mutants deficient in r-II exclusion.缺乏r-II排斥作用的λ噬菌体突变体。
Science. 1967 Dec 22;158(3808):1588-9. doi: 10.1126/science.158.3808.1588.
6
Oncogenes of RNA tumor viruses as determinants of cancer.作为癌症决定因素的RNA肿瘤病毒癌基因。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087-94. doi: 10.1073/pnas.64.3.1087.
7
Isolation and properties of rex - mutants of bacteriophage lambda.噬菌体λ的rex-突变体的分离与特性
J Virol. 1972 Oct;10(4):760-5. doi: 10.1128/JVI.10.4.760-765.1972.
8
Developmental pathways for the temperate phage: lysis vs lysogeny,温和噬菌体的发育途径：裂解与溶原化
Annu Rev Genet. 1972;6(0):157-90. doi: 10.1146/annurev.ge.06.120172.001105.
9
Mechanism of cell transformation by RNA tumor viruses.RNA肿瘤病毒导致细胞转化的机制。
Annu Rev Microbiol. 1971;25:609-48. doi: 10.1146/annurev.mi.25.100171.003141.
10
Use of tetrazolium salts for electron transport studies in meningopneumonitis. I. Reduced nicotinamide adenine dinucleotide system.四氮唑盐在脑膜肺炎电子传递研究中的应用。I. 还原型烟酰胺腺嘌呤二核苷酸系统。
J Bacteriol. 1965 Dec;90(6):1505-12. doi: 10.1128/jb.90.6.1505-1512.1965.
Zotero 插件