Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.
Laboratory of Phage Therapy, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Kładki 24, 80-822 Gdańsk, Poland.
Viruses. 2021 May 28;13(6):1013. doi: 10.3390/v13061013.
Bacteriophages are natural biological entities that limit the growth and amplification of bacteria. They are important stimulators of evolutionary variability in bacteria, and currently are considered a weapon against antibiotic resistance of bacteria. Nevertheless, apart from their antibacterial activity, phages may act as modulators of mammalian immune responses. In this paper, we focus on temperate phages able to execute the lysogenic development, which may shape animal or human immune response by influencing various processes, including phagocytosis of bacterial invaders and immune modulation of mammalian host cells.
噬菌体是限制细菌生长和扩增的天然生物实体。它们是细菌进化可变性的重要刺激因素，目前被认为是对抗细菌抗生素耐药性的一种手段。然而，除了其抗菌活性外，噬菌体还可以作为哺乳动物免疫反应的调节剂。在本文中，我们重点研究能够执行溶原性发育的温和噬菌体，它们可以通过影响各种过程来塑造动物或人类的免疫反应，包括细菌入侵的吞噬作用和哺乳动物宿主细胞的免疫调节。
