Amato Bruno, Farina Michele Angelo, Campisi Silvana, Ciliberti Marino, Donna Vincenzo Di, Florio Anna, Grasso Antonino, Miranda Rosario, Pompeo Francesco, Farina Eleonora, Serra Raffaele, Cirocchi Roberto, Calemma Francesca, Rocca Aldo, Compagna Rita
Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.
Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy.
Open Med (Wars). 2019 Dec 24;14:959-967. doi: 10.1515/med-2019-0113. eCollection 2019.
Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.
The aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.
Autologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.
The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.
These results support the CGF's clinical use for improving clinical outcomes in mixed ulcers of the legs.
与富血小板血浆（PRP）相比，浓缩生长因子（CGF）是第二代自体生长因子的浓缩物，是一种多因素刺激系统，可用于慢性皮肤溃疡的管理和治疗。
本研究旨在评估CGF相对于标准敷料的额外益处及其对愈合过程动态的影响。
在一项多中心对照随机研究中，从100例下肢慢性混合性溃疡（II期间歇性跛行患者的静脉溃疡）患者中获取自体CGF。
结果显示，在下肢混合性溃疡的愈合时间和稳定方面，CGF联合清洁和选择性加压使用具有显著优势。
这些结果支持CGF在改善腿部混合性溃疡临床结局方面的临床应用。
