Chen Guobing, Yung Raymond
Institute of Geriatric Immunology School of Medicine Jinan University Guangzhou China.
Department of Microbiology and Immunology School of Medicine Jinan University Guangzhou China.
Aging Med (Milton). 2019 Sep 8;2(3):157-161. doi: 10.1002/agm2.12078. eCollection 2019 Sep.
Geroscience posits that selected fundamental biological processes are the foundation of age-related chronic diseases and are responsible for the decline in physical and mental function in old age. Late-life chronic low-grade inflammation ("inflammaging") and altered signal transduction pathways in metabolism have been identified as two of the key themes in the aging process. Age-related changes in the immune and metabolic responses are also recognized as playing a critical pathogenic role in most common chronic medical conditions that plague the elderly. Emerging investigations emphasize the interconnectedness of the immune and metabolic responses in aging, an area of gerontological research that can be termed "meta-inflammaging."
老年科学认为，特定的基本生物学过程是与年龄相关的慢性疾病的基础，也是老年身心功能衰退的原因。晚年慢性低度炎症（“炎症衰老”）和代谢中信号转导途径的改变已被确定为衰老过程中的两个关键主题。免疫和代谢反应的年龄相关变化也被认为在困扰老年人的大多数常见慢性疾病中起着关键的致病作用。新出现的研究强调了衰老过程中免疫和代谢反应的相互联系，这一老年学研究领域可称为“元炎症衰老”。
