Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Palhoça, Santa Catarina 88137-270, Brazil; Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça, Santa Catarina 88137-270, Brazil.
Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça, Santa Catarina 88137-270, Brazil.
J Neuroimmunol. 2020 Mar 15;340:577145. doi: 10.1016/j.jneuroim.2020.577145. Epub 2020 Jan 10.
Lavandula angustifolia (LaEO) essential oil has been widely used by aromatherapy in the treatment of various clinical conditions, with evidence of its analgesic and anti-inflammatory potential. Our results demonstrate that sixty-five substances were identified in LaEO. Among the compounds found, the major ones were linalool (30.61%) and linalyl acetate (20.36%). We found that LaEO inhalation reduces mechanical hyperalgesia in conditions of chronic inflammatory and neuropathic pain. Furthermore, this effect seems to be mediated by peripheral and central opioid and cannabinoid 2 receptors. The findings of the present study suggests that the LaEO inhalation is effective on the chronic pain treatment.
狭叶薰衣草（LaEO）精油已被广泛应用于芳香疗法中，用于治疗各种临床病症，其具有镇痛和抗炎的潜力。我们的研究结果表明，LaEO 精油中鉴定出 65 种物质。在所发现的化合物中，主要成分是芳樟醇（30.61%）和乙酸芳樟酯（20.36%）。我们发现，LaEO 吸入可减轻慢性炎症性和神经性疼痛状态下的机械性痛觉过敏。此外，这种作用似乎是通过外周和中枢阿片类和大麻素 2 受体介导的。本研究的结果表明，LaEO 吸入对慢性疼痛的治疗有效。
