Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, People's Republic of China.
Virology. 2020 Mar;542:8-19. doi: 10.1016/j.virol.2020.01.003. Epub 2020 Jan 11.
The H3 subtype avian influenza virus (AIV) poses a threat to both animal and human health. In this study, phylogenetic analysis showed that the H3 AIVs had various genomic constellations and extensive reassortments, increasing genetic diversity and the emergence of new pathogenic viruses that might infect human beings. Molecular analysis demonstrated that the major molecular markers linked to drug resistance were identified in M genes of three studied viruses, and there might be wide range of resistant virus infections in poultry in the future. Although all the H3 viruses preferentially bound to the avian-type receptor, the growth kinetics experiments showed that the selected H3 viruses were capable of efficient replication in mammalian cells, suggesting a potential cross-species transmission of H3 viruses. Overall, our results emphasize the need for continued surveillance of H3 outbreaks and may also help us improve knowledge on H3 AIVs prevention and control.
H3 亚型禽流感病毒（AIV）对动物和人类健康构成威胁。本研究表明，H3 AIV 具有多种基因组构成和广泛的重配，增加了遗传多样性和新的可能感染人类的致病病毒的出现。分子分析表明，在所研究的三种病毒的 M 基因中鉴定出与耐药性相关的主要分子标记，未来家禽中可能会出现广泛的耐药病毒感染。尽管所有 H3 病毒都优先与禽型受体结合，但生长动力学实验表明，所选 H3 病毒能够在哺乳动物细胞中有效复制，这表明 H3 病毒可能存在跨物种传播的潜力。总的来说，我们的研究结果强调了需要继续监测 H3 爆发的情况，这也可能有助于我们提高对 H3 AIV 预防和控制的认识。
