Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS 38677, USA.
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS 38677, USA; Pii Center for Pharmaceutical Technology, The University of Mississippi, MS 38677, USA.
Carbohydr Polym. 2020 Oct 15;246:116519. doi: 10.1016/j.carbpol.2020.116519. Epub 2020 Jun 4.
Three-dimensional printing could serve as a platform to fabricate individualized medicines and complex-structured solid dosage forms. Herein, hot melt extrusion was coupled with 3D printing to develop a unique gastro retentive dosage form to personalize treatment of cinnarizine or other narrow absorption window drugs. The mechanical strength of the extruded strands was optimized for printing by combining two polymers, hydroxypropyl cellulose and vinylpyrrolidone vinyl acetate copolymer. The unit dose, floating force, and release profile were controlled by the printing parameters and object design. The tablets floated immediately within the FaSSGF, and floating force was relatively constant up to 12 h. Drug release followed zero-order kinetics and could be controlled from 6 h to ≥ 12 h. Input variables had a good correlation (R > 0.95) with unit dose, floating force, and dissolution profile (p < 0.05). Authors successfully proposed and tested a new paradigm of individualized medicine fabrication to meet individual patient needs.
三维打印可作为制造个体化药物和复杂结构固体制剂的平台。本文采用热熔挤出技术与 3D 打印技术相结合，开发了一种独特的胃滞留制剂，用于个体化治疗肉桂嗪或其他窄吸收窗药物。通过将两种聚合物羟丙纤维素和乙烯基吡咯烷酮-醋酸乙烯酯共聚物结合使用，优化了挤出丝的机械强度，以满足打印要求。通过打印参数和物体设计来控制单位剂量、漂浮力和释放曲线。片剂在 FaSSGF 中立即漂浮，并且漂浮力在 12 小时内相对恒定。药物释放遵循零级动力学，可以控制在 6 小时至≥12 小时之间。输入变量与单位剂量、漂浮力和溶解曲线（p<0.05）具有良好的相关性（R>0.95）。作者成功地提出并测试了一种新的个体化药物制造范例，以满足个体患者的需求。
