Suppr超能文献

从 L. 的种子中提取的成分

Constituents from the Seeds of L.

机构信息

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

College of pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.

出版信息

Molecules. 2020 Jan 19;25(2):411. doi: 10.3390/molecules25020411.

Abstract

Three new isoflavone glucosides, kudonol A-C (-), two new ester derivatives of phenylpropanoid, kudolignan A and B (-) and five known compounds, (-)-maackiain (), neoliquiritin (), methyl 4-coumarate (), methyl ferulate () and (+)-wikstromol (), were isolated from an extract of dried seeds of the traditional Chinese medicinal plant L. Their structures were established by NMR and HRESIMS data analyses. The monosaccharide part's configuration of isoflavone glucosides was confirmed by acid hydrolysis and analyzed by a JAsco OR-4090 chiral detector, comparing it to standard substance D-glucose. The cytotoxicity effects against HeLa, Hep3B, MCF-7 and H1299 cells were tested by CCK-8 assay.

摘要

从传统中药 L 的干种子提取物中分离得到三种新的异黄酮葡萄糖苷,kudonol A-C(-),两种新的苯丙素酯衍生物,kudolignan A 和 B(-)和五种已知化合物,(-)maackiain(),新甘草苷(),对羟基苯甲酸甲酯(),阿魏酸甲酯()和(+)wikstromol()。通过 NMR 和 HRESIMS 数据分析确定了它们的结构。通过酸水解和使用 JAsco OR-4090 手性检测器分析确定异黄酮葡萄糖苷的单糖部分的构型,并与标准物质 D-葡萄糖进行比较。通过 CCK-8 测定法测试了它们对 HeLa、Hep3B、MCF-7 和 H1299 细胞的细胞毒性作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d798/7024312/3b944276f86d/molecules-25-00411-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验