Center of Chemical Innovation for Sustainability (CIS) , Mae Fah Luang University , Chiang Rai 57100 , Thailand.
School of Science, Mae Fah Luang University , Chiang Rai 57100 , Thailand.
J Nat Prod. 2018 Aug 24;81(8):1835-1840. doi: 10.1021/acs.jnatprod.8b00321. Epub 2018 Aug 14.
The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.
对 Millettia extensa 茎提取物的首次植物化学研究导致分离和鉴定了六种新的异黄酮，即 millexatins A-F（1-6），以及 16 种已知化合物。这些新化合物的结构是根据它们的光谱数据确定的。Millexatin A（1）是一种罕见的异黄酮，在修饰的 A 环上含有三个异戊烯基单元。化合物 1、6、10、11 和 14 表现出有希望的抗菌活性，MIC 值为 2-8 μg/mL。
