阿尔茨海默病的多发性硬化症的成像生物标志物。
Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.
机构信息
Department of Radiology, Mayo Clinic, Rochester, MN.
Department of Neurology, Mayo Clinic, Rochester, MN.
出版信息
Ann Neurol. 2020 Apr;87(4):556-567. doi: 10.1002/ana.25684. Epub 2020 Feb 8.
OBJECTIVE
To investigate β-amyloid and tau depositions using Pittsburgh compound B (PiB) positron emission tomography (PET) and AV1451 tau PET imaging in aging multiple sclerosis (MS) patients.
METHODS
Patients with MS (n = 16) and controls (n = 80) matched for age, sex, and APOE ε4 status from the population-based Mayo Clinic Study of Aging who underwent PiB PET imaging were studied. Of these individuals, 12 patients with MS and 60 matching controls also underwent AV1451 tau PET. Cortical PiB and AV1451 standard uptake value ratios (SUVrs) from the entire cortex and previously determined Alzheimer disease (AD) signature regions in the same population were calculated for group comparisons and testing for associations with age.
RESULTS
AD signature PiB SUVr (odds ratio [OR] [95% confidence interval (CI)] = 0.52 [0.27-0.98], p = 0.044), total cortical PiB SUVr (OR [95% CI] = 0.52 [0.28-0.99], p = 0.048), and the frequency of abnormal PiB SUVrs (OR [95% CI] = 0.10 [0.01-0.90], p = 0.040) were lower in MS than controls. Although AD-signature and total cortical AV1451 SUVrs were not different between the groups, the frequency of abnormal AV1451 SUVrs was higher (OR [95% CI] = 10.65 [1.10-103.35], p = 0.041) in MS than controls. The association of AD signature PiB SUVr with age was steeper in the controls compared to patients with MS (estimate [95% CI] = -0.14 [-0.023 to -0.006], p = 0.002). Similarly, the association of total cortical PiB SUVr with age was steeper in the controls compared to patients with MS (estimate [95% CI] = -0.13 [-0.021 to -0.005], p = 0.002). There was no difference in the association of AV1451 SUVr findings with age between the MS patients and controls.
INTERPRETATION
Although both β-amyloid and tau are biomarkers of cognitive aging and AD, cortical β-amyloid deposition was lower in MS than age-matched controls, suggesting that some aspect of MS pathobiology retards the accumulation of β-amyloid but not the accumulation of tau. ANN NEUROL 2020;87:556-567.
目的
使用匹兹堡化合物 B（PiB）正电子发射断层扫描（PET）和 AV1451 tau PET 成像研究衰老多发性硬化症（MS）患者中的β-淀粉样蛋白和 tau 沉积。
方法
对来自基于人群的 Mayo 诊所衰老研究的接受 PiB PET 成像的年龄、性别和 APOE ε4 状态匹配的 MS 患者（n=16）和对照组（n=80）进行了研究。其中，12 名 MS 患者和 60 名匹配的对照组还接受了 AV1451 tau PET。为了进行组间比较和测试与年龄的关联，从同一人群中计算了整个皮质的皮质 PiB 和 AV1451 标准摄取值比（SUVr）以及先前确定的阿尔茨海默病（AD）特征区域的 SUVr。
结果
MS 患者的 AD 特征 PiB SUVr（比值比[OR] [95%置信区间（CI）] = 0.52 [0.27-0.98]，p = 0.044）、总皮质 PiB SUVr（OR [95% CI] = 0.52 [0.28-0.99]，p = 0.048）和异常 PiB SUVr 的频率（OR [95% CI] = 0.10 [0.01-0.90]，p = 0.040）均低于对照组。尽管 AD 特征和总皮质 AV1451 SUVr 在两组之间没有差异，但 MS 患者异常 AV1451 SUVr 的频率更高（OR [95% CI] = 10.65 [1.10-103.35]，p = 0.041）。与 MS 患者相比，对照组中 AD 特征 PiB SUVr 与年龄的关联更陡峭（估计值[95% CI] = -0.14 [-0.023 至 -0.006]，p = 0.002）。同样，与 MS 患者相比，对照组中总皮质 PiB SUVr 与年龄的关联更陡峭（估计值[95% CI] = -0.13 [-0.021 至 -0.005]，p = 0.002）。MS 患者和对照组之间 AV1451 SUVr 结果与年龄的关联没有差异。
结论
尽管β-淀粉样蛋白和 tau 都是认知衰老和 AD 的生物标志物，但 MS 患者的皮质β-淀粉样蛋白沉积低于年龄匹配的对照组，这表明 MS 发病机制的某些方面会延迟β-淀粉样蛋白的积累，但不会延迟 tau 的积累。ANN NEUROL 2020;87:556-567.
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