Institute of Pharmaceutical Biology, Heinrich Heine University, Duesseldorf, Germany.
Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Nat Prod Res. 2021 Nov;35(21):3578-3583. doi: 10.1080/14786419.2020.1715400. Epub 2020 Jan 23.
A new tetronic acid derivative () together with terrestric acid (), a known metabolite of species, was isolated from the soil fungus, FG9RK following fermentation on solid rice medium. The structure of was elucidated by one- and two-dimensional NMR and MS measurements. The absolute configuration of the oxygenated carbon in the side chain of was identified as by converting the compound into its Mosher ester whereas the absolute configuration of the lactone ring was deduced based on biogenetic considerations and comparison with .
一种新的四氢酸衍生物（）与地衣酸（）一起从土壤真菌 FG9RK 固体大米培养基发酵物中分离得到，地衣酸是 种已知的代谢物。通过一维和二维 NMR 和 MS 测量阐明了的结构。通过将化合物转化为莫舍尔酯，确定了侧链中含氧碳的绝对构型为，而内酯环的绝对构型则根据生物发生考虑和与的比较推断得出。
