Nadler Ronald D, Graham Charles E, Gosselin Robert E, Collins Delwood C
Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia.
Primate Research Institute, New Mexico State University, Holloman AFB, New Mexico.
Am J Primatol. 1985;9(4):273-284. doi: 10.1002/ajp.1350090404.
The objective of this study was to expand the data on menstrual cycle serum hormone patterns in female common chimpanzees, both in terms of the number of cycles analyzed and by the addition of data on testosterone levels. Samples were obtained from 11 unanesthetized animals trained for conscious blood withdrawal. LH, FSH, 17β-estradiol (E), progesterone (P), and testosterone (T) were measured by radioimmunoassay, genital swelling was recorded, and menstrual blood was noted. Concurrent midcycle elevations in LH and FSH and luteal phase elevations in progesterone suggested that the cycles were ovulatory. Detumescence of genital swelling occurred about 3 days after the midcycle LH peak, 1 day after the luteal phase nadir in E, and 1 day after P levels exceeded 5 ng/ml. These relationships provide further support for the use of genital swelling in monitoring progress of the menstrual cycle. The hormone patterns in the chimpanzees closely resembled those of the human females, but E and T levels were higher. The levels of E and T were higher and the midcycle elevation in T was broader in the chimpanzee than in gorillas and orangutans. This is of interest because E and T are implicated in the regulation of mating, and chimpanzees mate over a greater portion of the cycle than the other apes. These data indicate the need for further study of hormonal contributions to the different patterns of mating in the great apes. They also support the use of the female common chimpanzee as a model for the human female in endocrine studies of the menstrual cycle.
本研究的目的是扩充有关雌性普通黑猩猩月经周期血清激素模式的数据，包括所分析周期的数量以及增加睾酮水平的数据。样本取自11只经过训练可进行清醒采血的未麻醉动物。通过放射免疫分析法测量促黄体生成素（LH）、促卵泡生成素（FSH）、17β-雌二醇（E）、孕酮（P）和睾酮（T），记录生殖器肿胀情况，并留意月经血。LH和FSH在月经周期中期同时升高，孕酮在黄体期升高，表明这些周期有排卵现象。生殖器肿胀消退发生在月经周期中期LH峰值后约3天、E在黄体期降至最低点后1天以及P水平超过5 ng/ml后1天。这些关系为利用生殖器肿胀监测月经周期进展提供了进一步支持。黑猩猩的激素模式与人类女性的非常相似，但E和T水平更高。与大猩猩和猩猩相比，黑猩猩的E和T水平更高，且T在月经周期中期的升高范围更广。这很有意思，因为E和T与交配调节有关，而且黑猩猩在周期中的交配时间比其他猿类更长。这些数据表明需要进一步研究激素对大型猿类不同交配模式的影响。它们还支持将雌性普通黑猩猩用作人类女性月经周期内分泌研究的模型。
