Institut für Pharmazeutische Technologie TU Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany.
Institut für Pharmazeutische Technologie TU Braunschweig, Mendelssohnstraße 1, 38106 Braunschweig, Germany; Center of Pharmaceutical Engineering, Franz-Liszt-Str. 35a, 38106 Braunschweig, Germany.
Int J Pharm. 2020 Mar 30;578:119074. doi: 10.1016/j.ijpharm.2020.119074. Epub 2020 Jan 23.
Benzoyl peroxide (BPO) in the form of over the counter monotherapeutics or prescription-only combinations is a key component of topical acne therapy, but its unfavourable side effect profile reduces the therapeutic value of this compound. Various galenic approaches have been pursued to resolve this ambivalence, but only a few have managed to enter the market. This article aims to give a comprehensive overview of the published experimental vehicle systems and to identify the fundamental rationales. With regard to the formulation, an increase in the tolerability of BPO can essentially be achieved by combining BPO with re-fattening and moisturizing substances, by incorporating it and controlling its release, as well as by targeted deposition of the active ingredient at the site of action, i.e. drug targeting. Recently, novel particulate formulations have been proposed that combine several of these design principles and are expected to bring new developments in this dynamic field of research.
过氧化苯甲酰（BPO）以非处方单药或处方复方制剂的形式是局部治疗痤疮的关键成分，但它不利的副作用降低了这种化合物的治疗价值。已经采用了各种制剂方法来解决这种矛盾，但只有少数几种方法成功进入了市场。本文旨在全面概述已发表的实验载体系统，并确定其基本原理。就配方而言，通过将 BPO 与重新滋润和保湿物质结合、将其包含在内并控制其释放，以及通过将活性成分靶向沉积在作用部位（即药物靶向），可以从根本上提高 BPO 的耐受性。最近，提出了新的微粒制剂，这些制剂结合了这些设计原理中的几种，有望为这一充满活力的研究领域带来新的发展。
