基于超离子导体钾铁氧体的电化学多巴胺传感器。

Electrochemical dopamine sensor based on superionic conducting potassium ferrite.

机构信息

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, 130012, PR China.

Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang, 110034, China.

出版信息

Biosens Bioelectron. 2020 Apr 1;153:112045. doi: 10.1016/j.bios.2020.112045. Epub 2020 Jan 21.

DOI:10.1016/j.bios.2020.112045

PMID:31989940

Abstract

Ionic liquid composite electrodes have been widely utilized for the fabrication of electrochemical biosensors. However, the biosensing electrode modified with ionic conducting solids remains unexplored. Herein, we prepared a superionic conducting potassium ferrite (KFeO) under hydrothermal conditions for modifying glassy carbon electrode (GCE). The modified electrode (KFeO/GCE) showed an excellent electrocatalytic activity towards the oxidation of dopamine (DA). The oxidation peak currents increased linearly with increasing DA concentrations in the range of 1 μM-140 μM, and the detection limit is 0.22 μM (S/N = 3). The developed DA sensor exhibited not only good selectivity for the determination of DA without interfering from ascorbic acid (AA), uric acid (UA), glucose and inorganic ions, but also good reproducibility and stability. Furthermore, the sensor was applied to determine DA concentration in bovine serum and obtained a satisfied result. This study provides a new approach for developing electrochemical biosensors based on ionic conducting solid materials.

摘要

离子液体复合电极已广泛应用于电化学生物传感器的制备。然而，对于基于离子导电固体的生物传感电极的修饰仍有待探索。在此，我们在水热条件下制备了超离子导体钾铁氧体（KFeO），用于修饰玻碳电极（GCE）。修饰后的电极（KFeO/GCE）对多巴胺（DA）的氧化表现出优异的电催化活性。在 1 μM-140 μM 的范围内，氧化峰电流随 DA 浓度的增加呈线性增加，检测限为 0.22 μM（S/N=3）。所开发的 DA 传感器不仅对 DA 的测定具有良好的选择性，没有抗坏血酸（AA）、尿酸（UA）、葡萄糖和无机离子的干扰，而且还具有良好的重现性和稳定性。此外，该传感器还用于测定牛血清中的 DA 浓度，得到了满意的结果。本研究为基于离子导电固体材料开发电化学生物传感器提供了一种新方法。