Mukherjee Nabanita, Nolan Vikki G, Dunn John R, Banerjee Pratik
Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
Department of Infectious Diseases, Center of Excellence for Influenza Research and Surveillance (CEIRS), St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pathogens. 2020 Jan 24;9(2):78. doi: 10.3390/pathogens9020078.
Non-typhoidal (NTS) infection (salmonellosis) is one of the most prevalent gastrointestinal diseases throughout the world. Human infections caused by Newport, Javiana, and Mississippi serotypes have been observed to occur at higher rates on an annual basis in western Tennessee. The reason for the increased rate of NTS infection by these three serotypes in this region is not known. We conducted a case-case analysis to identify potential risk factors associated with the three serotypes using FoodNet data, obtained from the Tennessee Department of Health, consisting of 1578 culture-confirmed salmonellosis cases in Tennessee from 2013 through 2015. Among all the exposure variables tested (254 in total), we found contact with pet treats or chews in the seven days prior to illness was the factor that was significantly associated with these serotypes compared to other serotypes (odds ratio = 3.0 (95% confidence intervals 1.6, 5.5), < 0.0005). This study highlights the need for further investigation of potential exposures (other than pet treats or chews), including several possible environmental sources of NTS infection in humans.
非伤寒型（NTS）感染（沙门氏菌病）是全球最普遍的胃肠道疾病之一。在田纳西州西部，每年由纽波特、哈维亚纳和密西西比血清型引起的人类感染发生率较高。该地区这三种血清型导致的NTS感染率上升的原因尚不清楚。我们利用从田纳西州卫生部获取的FoodNet数据进行了病例对照分析，以确定与这三种血清型相关的潜在风险因素，这些数据包括2013年至2015年田纳西州1578例经培养确诊的沙门氏菌病病例。在所有测试的暴露变量（共254个）中，我们发现发病前七天与宠物零食或咀嚼物接触是与这些血清型显著相关的因素，与其他血清型相比（优势比 = 3.0（95%置信区间1.6, 5.5），< 0.0005）。本研究强调需要进一步调查潜在暴露因素（除宠物零食或咀嚼物外），包括人类NTS感染的几种可能环境来源。
