State Key Laboratory of Oral Diseases& West China School of Stomatology& National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China.
Molecules. 2020 Jan 24;25(3):516. doi: 10.3390/molecules25030516.
The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as "smart" DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.
口腔是一个独特的复杂生态系统，定植着大量的微生物物种。口腔与口腔健康以及系统性健康密切相关。许多因素可能导致口腔微生物群落组成的改变，从而导致口腔微环境的失调和口腔感染性疾病。局部治疗和口腔卫生程序是主要的治疗方法。目前，口腔药物递送系统（DDS）引起了广泛关注，被认为是口腔感染性疾病的重要辅助治疗方法。DDS 是一种能够将治疗药物或生物活性剂输送并释放到体内特定部位和特定速率的装置。与传统药物相比，它可以显著提高治疗效果，降低副作用。在综述中，总结了 DDS 在治疗口腔感染性疾病方面的最新应用，包括龋齿、牙周炎、种植体周围炎和口腔念珠菌病。此外，最近还报道了口腔刺激响应性 DDS，也称为“智能”DDS，它可以对口腔环境做出反应，提供更精确的药物输送或释放。本文还综述了口腔智能 DDS。讨论了其局限性，并展示了良好的研究前景。
