Department of Psychological Medicine, Faculty of Medical and Health Sciences, The University of Auckland, 1142, Auckland, New Zealand.
Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, 1142, Auckland, New Zealand.
Sci Rep. 2020 Jan 28;10(1):1291. doi: 10.1038/s41598-020-58129-w.
Poor maternal mental health has been associated with a myriad of pregnancy and child health complications. Obesity in pregnancy is known to increase one's risk of experiencing poor maternal mental health and associated physical and mental health complications. Probiotics may represent a novel approach to intervene in poor mental health and obesity. We conducted this pre-specified secondary analysis of the Healthy Mums and Babies (HUMBA) randomised controlled trial to investigate whether probiotics would improve maternal mental health outcomes up to 36 weeks of pregnancy. Two-hundred-and-thirty pregnant women with obesity (BMI ≥ 30.0 kg/m) were recruited and randomised to receive probiotic (Lactobacillus rhamnosus GG and Bifidobacterium lactis BB12, minimum 6.5 × 10 CFU) or placebo capsules. Depression, anxiety, and functional health and well-being were assessed at baseline (12-17 weeks' gestation) and 36 weeks of pregnancy. Depression scores remained stable and did not differ between the probiotic (M = 7.18, SD = 3.80) and placebo groups (M = 6.76, SD = 4.65) at 36 weeks (p-values > 0.05). Anxiety and physical well-being scores worsened over time irrespective of group allocation, and mental well-being scores did not differ between the two groups at 36 weeks. Probiotics did not improve mental health outcomes in this multi-ethnic cohort of pregnant women with obesity.
不良的孕产妇心理健康与众多妊娠和儿童健康并发症有关。众所周知，妊娠肥胖会增加孕产妇不良心理健康以及相关身体和心理健康并发症的风险。益生菌可能代表一种干预不良心理健康和肥胖的新方法。我们对健康妈妈和宝宝（HUMBA）随机对照试验进行了这项预先指定的二次分析，以调查益生菌是否会改善怀孕 36 周前的孕产妇心理健康结果。我们招募了 230 名肥胖（BMI≥30.0kg/m）的孕妇，并将她们随机分配到接受益生菌（鼠李糖乳杆菌 GG 和双歧杆菌 lactis BB12，最低 6.5×10 CFU）或安慰剂胶囊组。在基线（妊娠 12-17 周）和 36 周时评估抑郁、焦虑和功能健康和幸福感。在 36 周时，益生菌组（M=7.18，SD=3.80）和安慰剂组（M=6.76，SD=4.65）的抑郁评分保持稳定，且两组之间无差异（p 值>0.05）。焦虑和身体幸福感评分无论分组如何随时间恶化，且两组在 36 周时的心理健康评分无差异。在这个多民族肥胖孕妇队列中，益生菌并没有改善心理健康结果。
