姜黄素对接受脊髓麻醉剖宫产的子痫前期患者血清COX-2和IL-10的影响。
Curcumin's Effect on COX-2 and IL-10 Serum in Preeclampsia's Patient Undergo Sectio Caesarea with Spinal Anesthesia.
作者信息
Fadinie Wulan, Lelo Aznan, Wijaya Dadik Wahyu, Lumbanraja Sarma Nursani
机构信息
Department of Anesthesiology and Intensive Care, Universitas Sumatera Utara, Medan, Indonesia.
Department of Pharmacology and Therapeutics, Universitas Sumatera Utara, Medan, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Oct 14;7(20):3376-3379. doi: 10.3889/oamjms.2019.426. eCollection 2019 Oct 30.
BACKGROUND
Curcumin is a major component in curcuminoid which acts as an anti-inflammatory agent. Curcumin affects several biological markers that are thought to play a role in the pathogenesis of preeclampsia such as IL-10 and COX-2, resulting in an improvement in pregnant women with preeclampsia.
AIM
To see the effect of perioperative curcumin administration on IL-10 and COX-2 in preeclamptic patients undergoing caesarean section under spinal anaesthesia.
METHODS
This study was a double-blind, randomised clinical trial conducted at Pirngadi Hospital, USU Hospital and Sundari General Hospital Medan as a hospital network of Faculty of Medicine, North Sumatra University. Group 1 received a drug containing curcumin (as a treatment), and another group received a placebo (as a control).
RESULTS
There were no significant differences in the median values of COX-2 and IL-10 before and after treatment and also the p-values were greater than 0.05 in both groups (control and treatment).
CONCLUSION
There is no significant difference between the use of curcumin on serum COX-2 and IL-10 levels.
背景
姜黄素是姜黄素类化合物中的主要成分，具有抗炎作用。姜黄素会影响几种被认为在子痫前期发病机制中起作用的生物标志物，如白细胞介素-10（IL-10）和环氧化酶-2（COX-2），从而改善子痫前期孕妇的状况。
目的
观察围手术期给予姜黄素对在脊髓麻醉下接受剖宫产的子痫前期患者体内IL-10和COX-2的影响。
方法
本研究是一项双盲随机临床试验，在北苏门答腊大学医学院的医院网络——棉兰皮尔恩加迪医院、苏门答腊大学医院和桑达里综合医院进行。第1组接受含姜黄素的药物（作为治疗组），另一组接受安慰剂（作为对照组）。
结果
治疗前后COX-2和IL-10的中位数无显著差异，两组（对照组和治疗组）的p值均大于0.05。
结论
使用姜黄素对血清COX-2和IL-10水平无显著差异。
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