Ożarowski Marcin, Karpiński Tomasz M, Szulc Michał, Wielgus Karolina, Kujawski Radosław, Wolski Hubert, Seremak-Mrozikiewicz Agnieszka
Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants, Wojska Polskiego 71b, 60-630 Poznań, Poland.
Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Pharmaceuticals (Basel). 2021 Mar 16;14(3):269. doi: 10.3390/ph14030269.
The current health requirements set the direction in pharmacological research, especially as regards diseases that require improvement of existing therapeutic regimens. Such diseases include preeclampsia, which is a hypertensive disorder of pregnancy during which there occurs progressive increasing activation of the immune system through elevation of pro-inflammatory cytokines and antiangiogenic factors, which is dangerous for the mother and fetus. A promising field of research for new drugs to treat this disease is the study of natural phenolic compounds of plant origin and herbal extracts, which are complex matrices of chemical compounds with broad biological activities. Many plant substances with anti‑inflammatory and anti‑hypertensive properties are known, but studies in animal models of preeclampsia and clinical trials concerning this disease constitute a new and developing research trend of significant medical importance. The aim of our research review was to identify and analyze the results of already available studies on baicalin, curcumin, epigallocatechin gallate, punicalagin, quercetin, resveratrol, salvianolic acid A (danshensu), silibinin, and vitexin, as well as plant extracts from L., Mart., Lam., L., (L.) Gaertner, Ronniger, (Miq.) Miq. ex Havil., and L., which are potential and promising candidates for further research and for potential new therapies.
当前的健康需求为药理学研究指明了方向，尤其是对于那些需要改进现有治疗方案的疾病。这类疾病包括子痫前期，它是一种妊娠期高血压疾病，在此期间，通过促炎细胞因子和抗血管生成因子的升高，免疫系统会逐渐被激活，这对母亲和胎儿都很危险。治疗这种疾病的新药的一个有前景的研究领域是对植物来源的天然酚类化合物和草药提取物的研究，这些提取物是具有广泛生物活性的化合物的复杂基质。许多具有抗炎和抗高血压特性的植物物质是已知的，但子痫前期动物模型研究和关于这种疾病的临床试验构成了一个具有重要医学意义的新的且不断发展的研究趋势。我们的研究综述旨在识别和分析已有的关于黄芩苷、姜黄素、表没食子儿茶素没食子酸酯、石榴皮素、槲皮素、白藜芦醇、丹酚酸A（丹参素）、水飞蓟宾和牡荆素的研究结果，以及来自[具体植物拉丁名1]、[具体植物拉丁名2]、[具体植物拉丁名3]、[具体植物拉丁名4]、[具体植物拉丁名5]、[具体植物拉丁名6]、[具体植物拉丁名7]和[具体植物拉丁名8]的植物提取物的研究结果，这些都是进一步研究和潜在新疗法的有潜力且有前景的候选物。
