Yale University, School of Public Health.
Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
Psychol Med. 2021 May;51(7):1129-1139. doi: 10.1017/S0033291719004008. Epub 2020 Feb 3.
Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics.
This analysis pooled data from six longitudinal studies of adult survivors of civilian-related injuries admitted to general hospital emergency departments (EDs) in six countries (pooled N = 3083). Each study included at least three assessments of the clinician-administered PTSD scale in the first post-trauma year. Latent class growth analysis determined the proportion of participants exhibiting various PTSD symptom trajectories within and across the datasets. Multinomial logistic regression analyses examined demographic characteristics, type of event leading to the injury, and trauma history as predictors of trajectories differentiated by their initial severity and course.
Five trajectories were found across the datasets: Low (64.5%), Remitting (16.9%), Moderate (6.7%), High (6.5%), and Delayed (5.5%). Female gender, non-white race, prior interpersonal trauma, and assaultive injuries were associated with increased risk for initial PTSD reactions. Female gender and assaultive injuries were associated with risk for membership in the Delayed (v. Low) trajectory, and lower education, prior interpersonal trauma, and assaultive injuries with risk for membership in the High (v. Remitting) trajectory.
The results suggest that over 30% of civilian-related injury survivors admitted to EDs experience moderate-to-high levels of PTSD symptoms within the first post-trauma year, with those reporting assaultive violence at increased risk of both immediate and longer-term symptoms.
研究探索创伤后应激障碍(PTSD)症状的纵向过程记录了四种模态轨迹(低、缓解、高和延迟),不同研究的比例不同。异质性可能是由于创伤类型和患者人口统计学特征的差异。
本分析汇总了来自六个国家普通医院急诊部(ED)收治的平民相关创伤成年幸存者的六项纵向研究的数据(汇总 N=3083)。每个研究都包括在创伤后第一年至少三次使用临床医生管理的 PTSD 量表评估。潜在类别增长分析确定了在各数据集内和跨数据集显示各种 PTSD 症状轨迹的参与者比例。多项逻辑回归分析检查了人口统计学特征、导致受伤的事件类型和创伤史作为轨迹初始严重程度和进程差异的预测因素。
在各数据集之间发现了五个轨迹:低(64.5%)、缓解(16.9%)、中度(6.7%)、高(6.5%)和延迟(5.5%)。女性性别、非白色种族、既往人际创伤和攻击性伤害与初始 PTSD 反应的风险增加相关。女性性别和攻击性伤害与延迟(与低)轨迹的成员资格相关,而较低的教育程度、既往人际创伤和攻击性伤害与高(与缓解)轨迹的成员资格相关。
研究结果表明,超过 30%的平民相关创伤幸存者在创伤后第一年经历中等到高水平的 PTSD 症状,报告遭受攻击暴力的幸存者更有可能出现即刻和长期症状。