Department of Dermatology, Jinling Hospital, No. 305, Zhongshan East Rd., Nanjing 210002 Jiangsu Province, China.
Department of Dermatology, Jinling Hospital, No. 305, Zhongshan East Rd., Nanjing 210002 Jiangsu Province, China.
J Mycol Med. 2020 Apr;30(1):100915. doi: 10.1016/j.mycmed.2019.100915. Epub 2019 Dec 6.
Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mechanisms of azole resistance in A. fumigatus were presented and summarized and meanwhile the putative clinical relevance of these findings from bench work were discussed. Important aims are to gain more insight to mechanism of azole resistance and provide some efficient lead for prevention strategy.
由于抗真菌药物有限，以及世界各地唑类耐药的发生，曲霉菌感染日益被认为是一个全球性的健康问题。近年来，随着分子生物技术的应用，包括下一代测序、反向遗传学等，在临床和实验室研究中已经确定了更多的 cyp51 介导和非 cyp51 介导的唑类耐药机制。在这篇综述中，介绍和总结了烟曲霉唑类耐药的分子机制的最新研究，并同时讨论了这些来自实验室工作的发现的潜在临床意义。重要的目标是更深入地了解唑类耐药的机制，并为预防策略提供一些有效的线索。
