Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
J Nat Prod. 2008 Nov;71(11):1930-3. doi: 10.1021/np800564z. Epub 2008 Nov 6.
Three new ent-kaurane type diterpenes, broussonetones A-C (1-3), were isolated from leaves of Broussonetia papyrifera, together with seven known compounds, and their structures determined by 1D and 2D NMR and MS methods. Compounds 1-3 were marginal inhibitors of tyrosinase. Antioxidant assays showed them also to be inhibitors of xanthine oxidase. The mild inhibition of tyrosinase and significant inhibition of xanthine oxidase suggests that 1-3 could be useful ingredients in the development of skin-protecting cosmetics.
从构树的叶子中分离得到三个新的贝壳杉烷型二萜，broussonetones A-C（1-3），以及七个已知化合物，并通过 1D 和 2D NMR 和 MS 方法确定了它们的结构。化合物 1-3 是酪氨酸酶的边缘抑制剂。抗氧化测定表明它们也是黄嘌呤氧化酶的抑制剂。对酪氨酸酶的轻度抑制和对黄嘌呤氧化酶的显著抑制表明，1-3 可能是开发皮肤保护化妆品的有用成分。
