Mallo C, Zaidan R, Faure A, Brun J, Chazot G, Claustrat B
Service de Radiopharmacie et Radioanalyse, Hôpital de l'Antiquaille, Lyon, France.
Acta Endocrinol (Copenh). 1988 Dec;119(4):474-80. doi: 10.1530/acta.0.1190474.
An oral preparation of melatonin was administered daily at 22.00 h to 6 healthy volunteers during summer on 4 consecutive days (days 1-4). The daily dose was 8 mg of melatonin as a single. Three 24-h melatonin, cortisol and prolactin profiles were determined in plasma by radioimmunological methods: 1) before treatment (day 0); 2) the first day after the 4-day treatment had been stopped (day 5), 3) the third day after withdrawal of this treatment (day 7). For the melatonin rhythm, an advanced phase was observed at day 7 vs day 0, whereas the amplitude and the mesor were not modified, whatever the day. For the prolactin profile, a significant increase as compared with the control day (day 0) was detected only at day 7 between 19.00 and 21.00 h. No modification was recorded for the plasma cortisol secretion. These results suggest that melatonin, when administered at a high dose over a short period, can influence the endocrine rhythms, and especially its own endogenous secretion. This effect must be investigated over several days after the treatment has ended.
夏季时，连续4天（第1 - 4天）于每晚22:00给6名健康志愿者口服褪黑素制剂。每日剂量为8毫克褪黑素，单次服用。采用放射免疫法测定血浆中褪黑素、皮质醇和催乳素的3个24小时曲线：1）治疗前（第0天）；2）停止4天治疗后的第1天（第5天）；3）停止该治疗后的第3天（第7天）。对于褪黑素节律，与第0天相比，第7天观察到相位提前，而无论哪一天，其振幅和平均水平均未改变。对于催乳素曲线，仅在第7天的19:00至21:00之间检测到与对照日（第0天）相比有显著增加。血浆皮质醇分泌未见改变。这些结果表明，短期内高剂量服用褪黑素可影响内分泌节律，尤其是其自身的内源性分泌。治疗结束后的数天内必须对这种效应进行研究。
