Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, People's Republic of China.
Cardiovascular Research Institute, Wuhan University, Wuhan, People's Republic of China.
J Cardiovasc Transl Res. 2020 Oct;13(5):677-685. doi: 10.1007/s12265-019-09941-x. Epub 2020 Feb 4.
Whether intra-myocardial delivery of hydrogel can prevent post-infarct heart failure (HF) in a long follow-up period, especially after it is degraded, remains unclear. In this study, Dex-PCL-HEMA/PNIPAAm (DPHP) hydrogel was delivered into peri-infarct myocardium of rat when coronary artery was ligated, while PBS was employed as control. Twelve weeks later, compared with control, left ventricle remodeling was attenuated and cardiac function was preserved; serum brain natriuretic peptide, cardiac aldosterone, and pulmonary congestion were suppressed in hydrogel group. Pro-fibrogenic mRNA increased in infarct area while decreased in remote zone, as well as hypertrophic mRNA. These data proves DPHP hydrogel suppresses ventricular remodeling and HF by promoting fibrotic healing in infarct area and inhibiting reactive fibrosis and hypertrophy in remote zone. Timely intra-myocardial hydrogel implantation is an effective strategy to inhibit post-infarct cardiac remodeling and have a long-term beneficial effect even after it has been biodegraded.
心肌内递送电凝胶能否在长期随访中预防梗死后心力衰竭（HF），尤其是在其降解后，尚不清楚。在这项研究中，当冠状动脉结扎时，将 Dex-PCL-HEMA/PNIPAAm（DPHP）水凝胶递送至大鼠梗死周边心肌，而 PBS 作为对照。12 周后，与对照组相比，水凝胶组左心室重构减轻，心功能得以维持；血清脑钠肽、心脏醛固酮和肺淤血减少。梗死区的促纤维化 mRNA 增加，而远隔区的肥大 mRNA 减少。这些数据表明，DPHP 水凝胶通过促进梗死区的纤维化愈合和抑制远隔区的反应性纤维化和肥大，抑制心室重构和 HF。及时的心肌内水凝胶植入是一种有效的抑制梗死后心脏重构的策略，即使在其被生物降解后，也具有长期的有益效果。
