Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome.
Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.
J Biol Regul Homeost Agents. 2017 Apr-Jun;31(2 Suppl 1):197-202.
Diabetic patients are more prone to develop infections such as periodontal diseases. Bacteriotherapy with the concept of using good bacterial strains to replace the pathogenic ones emerged as a fascinating field due to the increasing incidence of antibiotic resistance. The aim of this study was to evaluate if a particular combination of probiotics (Lactobacillus Reuteri DSM 17938 and Lactobaciullus Reuteri ATCC PTA 5289) is useful in treating gingivitis in diabetic patients. Eighty adult patients with diagnosis of controlled diabetes type II and gingivitis were enrolled for this study and randomized in two groups. Only oral hygiene instructions were given. Bacteriotherapy (Lactobacillus Reuteri) was administered to test group. Outcome measures were presence of Plaque (P.I.) and Bleeding on Probing (B.O.P.). Data were collected at baseline and after 30 days. At 30 days, both groups showed a statistically significant clinical indexes reduction from baseline. More reduction was present in the test group for P.I. (14%±6) and for B.O.P. (18%±4) and was statistically significant (p less than 0.05). Within the limitations of this study, bacteriotherapy can be considered effective in reducing plaque and BOP in patients with controlled diabetes type II and gingivitis.
糖尿病患者更容易发生感染，如牙周病。由于抗生素耐药性的发生率不断增加，使用有益细菌菌株替代致病菌株的细菌治疗作为一个迷人的领域出现了。本研究旨在评估特定的益生菌（鼠李糖乳杆菌 DSM 17938 和鼠李糖乳杆菌 ATCC PTA 5289）组合是否对糖尿病患者的牙龈炎有效。本研究纳入了 80 名诊断为 II 型糖尿病且患有牙龈炎的成年患者，并将其随机分为两组。仅给予口腔卫生指导。实验组给予细菌治疗（鼠李糖乳杆菌）。观察指标为菌斑指数（PI）和探诊出血（BOP）。数据在基线和 30 天后收集。30 天后，两组的临床指数均从基线显著降低。实验组的 PI（14%±6）和 BOP（18%±4）降低更明显，且具有统计学意义（p 小于 0.05）。在本研究的限制范围内，可以认为细菌治疗可有效减少 II 型糖尿病和牙龈炎患者的菌斑和 BOP。
