Jakočiūnas Tadas, Klitgaard Andreas K, Kontou Eftychia Eva, Nielsen Julie Bang, Thomsen Emil, Romero-Suarez David, Blin Kai, Petzold Christopher J, Gin Jennifer W, Tong Yaojun, Gotfredsen Charlotte Held, Charusanti Pep, Frandsen Rasmus J N, Weber Tilmann, Lee Sang Yup, Jensen Michael K, Keasling Jay D
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark.
Joint BioEnergy Institute, Emeryville, CA, USA.
Synth Syst Biotechnol. 2020 Jan 23;5(1):11-18. doi: 10.1016/j.synbio.2020.01.004. eCollection 2020 Mar.
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.
为了加速向生物基生产的转变，并克服天然和人工生物合成途径在工业相关生物体中复杂的功能实现问题，需要开发新的、通用的生物基生产平台。在此，我们展示了一种用于细菌芳香族聚酮化合物生物合成的新型酵母基平台。该平台基于一种合成聚酮合酶系统，首次实现了在真核宿主中细菌芳香族聚酮化合物的生物合成。
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