Kim Jiwon, Hoang Nguyen Tran Phuong, Lee Sun-Mi
Clean Energy Research Center, Korea Institute of Science and Technology (KIST), Seoul, South Korea.
Department of Biotechnology, Korea University, Seoul, South Korea.
Front Bioeng Biotechnol. 2020 Dec 14;8:594061. doi: 10.3389/fbioe.2020.594061. eCollection 2020.
Yeasts are promising industrial hosts for sustainable production of fuels and chemicals. Apart from efficient bioethanol production, yeasts have recently demonstrated their potential for biodiesel production from renewable resources. The fuel-oriented product profiles of yeasts are now expanding to include non-native chemicals with the advances in synthetic biology. In this review, current challenges and opportunities in yeast engineering for sustainable production of non-native chemicals will be discussed, with a focus on the comparative evaluation of a bioethanol-producing strain and a biodiesel-producing strain. Synthetic pathways diverging from the distinctive cellular metabolism of these yeasts guide future directions for product-specific engineering strategies for the sustainable production of non-native chemicals on an industrial scale.
酵母是可持续生产燃料和化学品的理想工业宿主。除了高效生产生物乙醇外，酵母最近还展现出了利用可再生资源生产生物柴油的潜力。随着合成生物学的发展，酵母以燃料为导向的产品种类正在不断扩展，已涵盖非天然化学品。在本综述中，我们将讨论酵母工程在可持续生产非天然化学品方面面临的当前挑战和机遇，重点是对一株生物乙醇生产菌株和一株生物柴油生产菌株的比较评估。源自这些酵母独特细胞代谢的合成途径为工业规模可持续生产非天然化学品的特定产品工程策略指明了未来方向。
