Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD 4350, Australia.
Mar Drugs. 2020 Jan 31;18(2):97. doi: 10.3390/md18020097.
Carrageenans are thickening and gelling agents that may provide health benefits. Iota (ι)-carrageenan, a linear sulfated polysaccharide, is produced by the red seaweed, . This study investigated the potential of this seaweed as a functional food for the reversal of metabolic syndrome and possible mechanisms. Male Wistar rats were divided into four groups in a 16-week protocol: corn starch diet-fed rats (C); C rats supplemented with 5% for the last 8 weeks (CSF); high-carbohydrate, high-fat diet-fed rats (H); and H rats supplemented with 5% for the last 8 weeks (HSF). was produced in tank-based aquaculture yielding 27 g dry weight/day/m of culture area. H rats developed obesity, hypertension, dyslipidaemia, glucose intolerance, fatty liver and increased left ventricular collagen deposition. supplementation decreased body weight, abdominal and liver fat, systolic blood pressure, plasma total cholesterol concentrations, and plasma activities of alanine transaminase and aspartate transaminase. supplementation modulated gut microbiota without changing the Firmicutes to Bacteroidetes ratio. improved symptoms of high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Possible mechanisms include a reduced infiltration of inflammatory cells into organs as well as prebiotic actions in the gastrointestinal tract.
卡拉胶是一种增稠和胶凝剂，可能对健康有益。iota（ι）-卡拉胶是一种线性硫酸化多糖，由红海藻产生。本研究探讨了这种海藻作为功能性食品逆转代谢综合征的潜力及其可能的机制。雄性 Wistar 大鼠在 16 周的方案中分为四组：玉米淀粉饮食喂养的大鼠（C）；最后 8 周补充 5% 的 C 饮食（CSF）；高碳水化合物、高脂肪饮食喂养的大鼠（H）；最后 8 周补充 5% 的 H 饮食（HSF）。在基于罐的水产养殖中生产，每天每平方米培养面积产生 27 克干重。H 型大鼠出现肥胖、高血压、血脂异常、葡萄糖不耐受、脂肪肝和左心室胶原沉积增加。补充可降低体重、腹部和肝脏脂肪、收缩压、血浆总胆固醇浓度以及丙氨酸转氨酶和天冬氨酸转氨酶的血浆活性。补充可调节肠道微生物群，而不改变厚壁菌门与拟杆菌门的比例。改善了高碳水化合物、高脂肪饮食诱导的代谢综合征大鼠的症状。可能的机制包括减少炎症细胞浸润到器官以及胃肠道中的益生元作用。
