一项随机、双盲、安慰剂对照研究，比较利多卡因与酮咯酸或曲安奈德联合用药与单独使用利多卡因治疗软组织损伤的疗效。
Randomized, double-blind, Placebo-Controlled Study to Compare the Efficacy of Combination of Lidocaine with ketorolac or triamcinolone versus Lidocaine Alone for Soft Tissue Injuries.
作者信息
Sindhupakorn Bura, Jomkoh Darawan, Namkuntee Theeranit
机构信息
Orthopedic Department, School of Medicine, Suranaree Medical Institute, Suranaree University of Technology, 111 University Ave, Muang District, Nakhon Ratchasima Province, 30000, Thailand.
出版信息
J Orthop. 2020 Jan 28;20:135-143. doi: 10.1016/j.jor.2020.01.043. eCollection 2020 Jul-Aug.
Abstract
BACKGROUND
Corticosteroid and Ketorolac tromethamine is a pain reducing.
OBJECTIVE
The primary objective was pain intensity scores (VAS) in 10, 30, 60 min, 2, 6 h, 1, and 7 days.
METHOD
120 patients were randomized. The placebo group (normal saline) and experimental groups (ketorolac 30 mg, 60 mg, triamcinolone 10 mg, 20 mg, and 40 mg, respectively) were compared.
RESULT
VAS at 60 min, 2, 6 h, 1 and 7 days was significantly different (P < 0.05). Ketorolac 30 mg, 60 mg, and triamcinolone 10 mg shown non inferiority to triamcinolone 40 mg.
CONCLUSIONS
ketorolac was considered equal to triamcinolone.
摘要
背景
皮质类固醇和酮咯酸氨丁三醇具有减轻疼痛的作用。
目的
主要目的是观察10分钟、30分钟、60分钟、2小时、6小时、1天和7天时的疼痛强度评分（视觉模拟评分法）。
方法
将120例患者随机分组。比较安慰剂组（生理盐水）和实验组（分别为30毫克、60毫克酮咯酸，10毫克、20毫克和40毫克曲安奈德）。
结果
60分钟、2小时、6小时、1天和7天时的视觉模拟评分法有显著差异（P<0.05）。30毫克、60毫克酮咯酸和10毫克曲安奈德显示出不劣于40毫克曲安奈德。
结论
酮咯酸被认为与曲安奈德等效。
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Randomized, double-blind, Placebo-Controlled Study to Compare the Efficacy of Combination of Lidocaine with ketorolac or triamcinolone versus Lidocaine Alone for Soft Tissue Injuries.一项随机、双盲、安慰剂对照研究，比较利多卡因与酮咯酸或曲安奈德联合用药与单独使用利多卡因治疗软组织损伤的疗效。
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