Huang Yaping, Li Guo-Min
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 USA.
Cell Biosci. 2020 Feb 3;10:10. doi: 10.1186/s13578-020-0379-7. eCollection 2020.
DNA mismatch repair (MMR) maintains replication fidelity by correcting mispaired nucleotides incorporated by DNA polymerases. Defects in MMR lead to cancers characterized by microsatellite instability. Recently, chromatin mechanisms that regulate MMR have been discovered, which sheds new light on MMR deficiency and its role in tumorigenesis. This review summarizes these chromatin-level mechanisms that regulate MMR and their implications for tumor development.
DNA错配修复（MMR）通过校正DNA聚合酶掺入的错配核苷酸来维持复制保真度。MMR缺陷会导致以微卫星不稳定性为特征的癌症。最近，已发现调控MMR的染色质机制，这为MMR缺陷及其在肿瘤发生中的作用提供了新的线索。本综述总结了这些调控MMR的染色质水平机制及其对肿瘤发展的影响。
