Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Adv Exp Med Biol. 2020;1225:127-135. doi: 10.1007/978-3-030-35727-6_9.
Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) constitute the human γ-herpesviruses and two of the seven human tumor viruses. In addition to their viral oncogenes that primarily belong to the latent infection programs of these viruses, they encode proteins that condition the microenvironment. Many of these are early lytic gene products and are only expressed in a subset of infected cells of the tumor mass. In this chapter I will describe their function and the evidence that targeting them in addition to the latent oncogenes could be beneficial for the treatment of EBV- and KSHV-associated malignancies.
爱泼斯坦-巴尔病毒 (EBV) 和卡波西肉瘤相关疱疹病毒 (KSHV) 构成了人类 γ-疱疹病毒，也是七种人类肿瘤病毒中的两种。除了它们的病毒癌基因，这些癌基因主要属于这些病毒的潜伏感染程序外，它们还编码能够调节微环境的蛋白质。其中许多是早期裂解基因产物，仅在肿瘤块中受感染细胞的亚群中表达。在本章中，我将描述它们的功能以及针对这些病毒和潜伏癌基因的靶点进行治疗可能对 EBV 和 KSHV 相关恶性肿瘤有益的证据。
