Division of General Surgery, Trauma, and Surgical Critical Care, Department of Surgery, New Haven, CT.
Yale Center for Analytical Sciences Yale School of Public Health, New Haven, CT.
J Am Coll Surg. 2020 Jun;230(6):966-973.e10. doi: 10.1016/j.jamcollsurg.2019.10.018. Epub 2020 Feb 4.
The American College of Surgeons maintains that surgical care in the US has not reached optimal safety and quality. This can be driven partially by higher-risk, emergency operations in geriatric patients. We therefore sought to answer 2 questions: First, to what degree does standardized postoperative mortality vary in hospitals performing nonelective operations in geriatric patients? Second, can the differences in hospital-based mortality be explained by patient-, operative-, and hospital-level characteristics among outlier institutions?
Patients 65 years and older who underwent 1 of 8 common emergency general surgery operations were identified using the California State Inpatient Database (2010 to 2011). Expected mortality was obtained from hierarchical, Bayesian mixed-effects logistic regression models. A risk-adjusted hospital-level standardized mortality ratio (SMR) was calculated from observed-to-expected in-hospital deaths. "Outlier" hospitals had an SMR 80% CI that did not cross the mean SMR of 1.0. High-mortality (SMR >1.0) and low-mortality (SMR <1.0) outliers were compared.
We included 24,207 patients from 107 hospitals. SMRs varied widely, from 2.3 (highest) to 0.3 (lowest). Eleven hospitals (10.3%) were poor-performing high-SMR outliers, and 10 hospitals (9.3%) were exceptional-performing low-SMR outliers. SMR was 3 times worse in the high-SMR compared with the low-SMR group (1.7 vs 0.6; p < 0.001). Patient-, operation-, and hospital-level characteristics were equivalent among outlier-hospitals.
Significant hospital variation exists in standardized mortality after common general surgery operations done emergently in older patients. More than 10% of institutions have substantial excess mortality. These findings confirm that the safety of emergency operation in geriatric patients can be significantly improved by decreasing the wide variability in mortality outcomes.
美国外科医师学院认为,美国的外科护理尚未达到最佳的安全和质量水平。这在一定程度上可以归因于老年患者中风险更高的紧急手术。因此,我们试图回答两个问题:第一,在为老年患者进行非选择性手术的医院中,标准化术后死亡率的差异程度如何?第二,在异常值机构中,基于医院的死亡率差异能否用患者、手术和医院水平特征来解释?
使用加利福尼亚州住院患者数据库(2010 年至 2011 年),确定了 107 家医院中接受 8 种常见紧急普通外科手术之一的 65 岁及以上患者。使用分层贝叶斯混合效应逻辑回归模型获得预期死亡率。通过观察到的与预期院内死亡的比值计算风险调整后的医院水平标准化死亡率比(SMR)。SMR 的 80%置信区间未跨越平均值 1.0 的“异常值”医院被视为异常值医院。高死亡率(SMR>1.0)和低死亡率(SMR<1.0)异常值医院进行比较。
我们纳入了来自 107 家医院的 24207 名患者。SMR 差异很大,从最高的 2.3 到最低的 0.3。11 家医院(10.3%)为表现不佳的高 SMR 异常值医院,10 家医院(9.3%)为表现优异的低 SMR 异常值医院。高 SMR 组的 SMR 比低 SMR 组差 3 倍(1.7 比 0.6;p<0.001)。异常值医院的患者、手术和医院水平特征相当。
在为老年患者紧急进行的普通外科手术后,标准化死亡率存在显著的医院间差异。超过 10%的机构存在大量的超额死亡率。这些发现证实,通过降低死亡率结果的广泛变异性,可以显著提高老年患者急诊手术的安全性。