Alpeeva Elena, Sukhanov Yury, Vorotelyak Ekaterina
N.K. Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Department of Cell Biology, Vavilov str. 26, 119334 Moscow, Russia.
Biomedicines. 2020 Feb 5;8(2):25. doi: 10.3390/biomedicines8020025.
This review describes achievements of Russian cell-based regenerative medicine in different periods of time depending on the legislation and politics, and future prospects for its commercialization and wide application with an emphasis on products devised for skin regeneration. The world's experience in tissue engineering began with the development of living skin equivalents, utilizing a biopolymer matrix and cells at the very beginning of the 1980s. During this period, the USSR kept abreast with the times and also conducted studies on skin wound healing, implementing modern cell techniques. However, there soon emerged a gap between scientific advancement and practical application. Due to bureaucratic and economic reasons, investigations of Russian scientists posed significant deterrents in blocking the way to large-scale, legal and clinical use. After the breakup of the USSR, there were no institutions that could implement scientific inventions into full-scale manufacturing for clinical application. At the same time, accumulating scientific and practical experience allowed for the maintenance of biomedical research and its readiness for market entry at present. Recently developed legislation opens up new opportunities in this field in Russia. There are a growing number of studies on the development of novel products for regenerative medicine, bringing hope for its rapid progress.
本综述描述了俄罗斯基于细胞的再生医学在不同时期根据立法和政策所取得的成就，以及其商业化和广泛应用的未来前景，重点关注用于皮肤再生的产品。世界组织工程学的经验始于20世纪80年代初活体皮肤替代物的开发，最初利用生物聚合物基质和细胞。在此期间，苏联与时俱进，也开展了皮肤伤口愈合研究，采用了现代细胞技术。然而，科学进步与实际应用之间很快出现了差距。由于官僚主义和经济原因，俄罗斯科学家的研究对大规模、合法和临床应用构成了重大阻碍。苏联解体后，没有机构能够将科学发明转化为全面的临床应用制造。与此同时，积累的科学和实践经验使得生物医学研究得以维持，并为目前进入市场做好了准备。最近制定的立法为俄罗斯该领域带来了新机遇。关于再生医学新产品开发的研究越来越多，为其快速发展带来了希望。
